Wnt signaling enhances the activation and survival of human hepatic stellate cells

Sun Jung Myung; Jung Hwan Yoon; Geum Youn Gwak; Won Kim; Jeong Hoon Lee; Kang Mo Kim; Chan Soo Shin; Ja June Jang; Sung Hee Lee; Soo Mi Lee; Hyo Suk Lee

doi:10.1016/j.febslet.2007.05.050

Wnt signaling enhances the activation and survival of human hepatic stellate cells

Sun Jung Myung
, Jung Hwan Yoon
, Geum Youn Gwak
, Won Kim
, Jeong Hoon Lee
, Kang Mo Kim
, Chan Soo Shin
, Ja June Jang
, Sung Hee Lee
, Soo Mi Lee
, Hyo Suk Lee

Seoul National University

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we determined if Wnt signaling modulates hepatic stellate cell (HSC) activation and survival. Wnt3A treatment significantly activated human HSCs, while this was inhibited in secreted frizzled-related protein 1 (sFRP1) overexpressing cells. Wnt3A treatment significantly suppressed TRAIL-induced apoptosis in control HSCs versus sFRP1 over-expressing cells. Particularly, caspase 3 was more activated in sFRP1 over-expressing cells following TRAIL and Wnt3A treatment. These observations imply that Wnt signaling promotes hepatic fibrosis by enhancing HSC activation and survival.

Original language	English
Pages (from-to)	2954-2958
Number of pages	5
Journal	FEBS Letters
Volume	581
Issue number	16
DOIs	https://doi.org/10.1016/j.febslet.2007.05.050
State	Published - 26 Jun 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Fibrosis
Hepatic stellate cell
Secreted frizzled-related protein 1
Wnt

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10.1016/j.febslet.2007.05.050

Cite this

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title = "Wnt signaling enhances the activation and survival of human hepatic stellate cells",

abstract = "Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we determined if Wnt signaling modulates hepatic stellate cell (HSC) activation and survival. Wnt3A treatment significantly activated human HSCs, while this was inhibited in secreted frizzled-related protein 1 (sFRP1) overexpressing cells. Wnt3A treatment significantly suppressed TRAIL-induced apoptosis in control HSCs versus sFRP1 over-expressing cells. Particularly, caspase 3 was more activated in sFRP1 over-expressing cells following TRAIL and Wnt3A treatment. These observations imply that Wnt signaling promotes hepatic fibrosis by enhancing HSC activation and survival.",

keywords = "Apoptosis, Fibrosis, Hepatic stellate cell, Secreted frizzled-related protein 1, Wnt",

author = "Myung, \{Sun Jung\} and Yoon, \{Jung Hwan\} and Gwak, \{Geum Youn\} and Won Kim and Lee, \{Jeong Hoon\} and Kim, \{Kang Mo\} and Shin, \{Chan Soo\} and Jang, \{Ja June\} and Lee, \{Sung Hee\} and Lee, \{Soo Mi\} and Lee, \{Hyo Suk\}",

year = "2007",

month = jun,

day = "26",

doi = "10.1016/j.febslet.2007.05.050",

language = "English",

volume = "581",

pages = "2954--2958",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc",

number = "16",

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TY - JOUR

T1 - Wnt signaling enhances the activation and survival of human hepatic stellate cells

AU - Myung, Sun Jung

AU - Yoon, Jung Hwan

AU - Gwak, Geum Youn

AU - Kim, Won

AU - Lee, Jeong Hoon

AU - Kim, Kang Mo

AU - Shin, Chan Soo

AU - Jang, Ja June

AU - Lee, Sung Hee

AU - Lee, Soo Mi

AU - Lee, Hyo Suk

PY - 2007/6/26

Y1 - 2007/6/26

N2 - Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we determined if Wnt signaling modulates hepatic stellate cell (HSC) activation and survival. Wnt3A treatment significantly activated human HSCs, while this was inhibited in secreted frizzled-related protein 1 (sFRP1) overexpressing cells. Wnt3A treatment significantly suppressed TRAIL-induced apoptosis in control HSCs versus sFRP1 over-expressing cells. Particularly, caspase 3 was more activated in sFRP1 over-expressing cells following TRAIL and Wnt3A treatment. These observations imply that Wnt signaling promotes hepatic fibrosis by enhancing HSC activation and survival.

AB - Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we determined if Wnt signaling modulates hepatic stellate cell (HSC) activation and survival. Wnt3A treatment significantly activated human HSCs, while this was inhibited in secreted frizzled-related protein 1 (sFRP1) overexpressing cells. Wnt3A treatment significantly suppressed TRAIL-induced apoptosis in control HSCs versus sFRP1 over-expressing cells. Particularly, caspase 3 was more activated in sFRP1 over-expressing cells following TRAIL and Wnt3A treatment. These observations imply that Wnt signaling promotes hepatic fibrosis by enhancing HSC activation and survival.

KW - Apoptosis

KW - Fibrosis

KW - Hepatic stellate cell

KW - Secreted frizzled-related protein 1

KW - Wnt

UR - https://www.scopus.com/pages/publications/34250207000

U2 - 10.1016/j.febslet.2007.05.050

DO - 10.1016/j.febslet.2007.05.050

M3 - Article

C2 - 17544413

AN - SCOPUS:34250207000

SN - 0014-5793

VL - 581

SP - 2954

EP - 2958

JO - FEBS Letters

JF - FEBS Letters

IS - 16

ER -

Wnt signaling enhances the activation and survival of human hepatic stellate cells

Abstract

UN SDGs

Keywords

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