Vitamin D-receptor polymorphisms and non-tuberculous mycobacterial lung disease in Korean patients

S. Park; E. J. Kim; S. H. Lee; G. Y. Suh; M. P. Chung; H. Kim; O. J. Kwon; W. J. Koh

Vitamin D-receptor polymorphisms and non-tuberculous mycobacterial lung disease in Korean patients

S. Park, E. J. Kim, S. H. Lee, G. Y. Suh, M. P. Chung, H. Kim, O. J. Kwon, W. J. Koh

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

This study investigated the potential role of vitamin Dreceptor (VDR) gene polymorphisms in susceptibility to lung disease caused by non-tuberculous mycobacteria (NTM). TaqI and Fokl polymorphisms were compared in 124 patients and 127 controls. The genotype, allele and haplotype frequencies did not differ between patients and controls. TaqI and Fokl polymorphisms of the VDR gene do not appear to be responsible for host susceptibility to NTM lung disease, at least in this Korean population. An association cannot, however, be completely ruled out, as only two single nucleotide polymorphisms of the VDR gene were studied in this report.

Original language	English
Pages (from-to)	698-700
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	12
Issue number	6
State	Published - Jun 2008
Externally published	Yes

Keywords

Atypical mycobacteria
Genetic predisposition to disease
Lung disease
Point mutation
Vitamin D

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title = "Vitamin D-receptor polymorphisms and non-tuberculous mycobacterial lung disease in Korean patients",

abstract = "This study investigated the potential role of vitamin Dreceptor (VDR) gene polymorphisms in susceptibility to lung disease caused by non-tuberculous mycobacteria (NTM). TaqI and Fokl polymorphisms were compared in 124 patients and 127 controls. The genotype, allele and haplotype frequencies did not differ between patients and controls. TaqI and Fokl polymorphisms of the VDR gene do not appear to be responsible for host susceptibility to NTM lung disease, at least in this Korean population. An association cannot, however, be completely ruled out, as only two single nucleotide polymorphisms of the VDR gene were studied in this report.",

keywords = "Atypical mycobacteria, Genetic predisposition to disease, Lung disease, Point mutation, Vitamin D",

author = "S. Park and Kim, \{E. J.\} and Lee, \{S. H.\} and Suh, \{G. Y.\} and Chung, \{M. P.\} and H. Kim and Kwon, \{O. J.\} and Koh, \{W. J.\}",

year = "2008",

month = jun,

language = "English",

volume = "12",

pages = "698--700",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union Against Tuberculosis and Lung Disease ",

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T1 - Vitamin D-receptor polymorphisms and non-tuberculous mycobacterial lung disease in Korean patients

AU - Park, S.

AU - Kim, E. J.

AU - Lee, S. H.

AU - Suh, G. Y.

AU - Chung, M. P.

AU - Kim, H.

AU - Kwon, O. J.

AU - Koh, W. J.

PY - 2008/6

Y1 - 2008/6

N2 - This study investigated the potential role of vitamin Dreceptor (VDR) gene polymorphisms in susceptibility to lung disease caused by non-tuberculous mycobacteria (NTM). TaqI and Fokl polymorphisms were compared in 124 patients and 127 controls. The genotype, allele and haplotype frequencies did not differ between patients and controls. TaqI and Fokl polymorphisms of the VDR gene do not appear to be responsible for host susceptibility to NTM lung disease, at least in this Korean population. An association cannot, however, be completely ruled out, as only two single nucleotide polymorphisms of the VDR gene were studied in this report.

AB - This study investigated the potential role of vitamin Dreceptor (VDR) gene polymorphisms in susceptibility to lung disease caused by non-tuberculous mycobacteria (NTM). TaqI and Fokl polymorphisms were compared in 124 patients and 127 controls. The genotype, allele and haplotype frequencies did not differ between patients and controls. TaqI and Fokl polymorphisms of the VDR gene do not appear to be responsible for host susceptibility to NTM lung disease, at least in this Korean population. An association cannot, however, be completely ruled out, as only two single nucleotide polymorphisms of the VDR gene were studied in this report.

KW - Atypical mycobacteria

KW - Genetic predisposition to disease

KW - Lung disease

KW - Point mutation

KW - Vitamin D

UR - https://www.scopus.com/pages/publications/45349084739

M3 - Article

C2 - 18492342

AN - SCOPUS:45349084739

SN - 1027-3719

VL - 12

SP - 698

EP - 700

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 6

ER -

Vitamin D-receptor polymorphisms and non-tuberculous mycobacterial lung disease in Korean patients

Abstract

Keywords

UN SDGs

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