Utility of the Seoul Cognitive Status Test to detect amyloid status in mild cognitive impairment

Background: Investigating amyloid-β (Aβ) status could offer clinical implications for the identification of and intervention for individuals at higher risk of dementia due to Alzheimer's disease (AD). The use of computerized cognitive tests has been considered valuable in detecting Aβ positivity. Objective: This study aims to examine the predictive accuracy of the Seoul Cognitive Status Test (Seoul CST) for Aβ-positive mild cognitive impairment (Aβ+ MCI). Methods: A total of 138 patients with MCI who completed the Seoul CST and underwent Aβ positron emission tomography (PET) were included in this study. Results: Participants with Aβ+ MCI performed worse in the backward task of the Visual Span Test and all memory tasks except the immediate recall of the Word Place Association Test. The composite score was developed by averaging the age-, sex-, and education-adjusted Z-scores of the tasks showing significant differences between Aβ+ and Aβ- (Aβ-negative) MCI. This composite score exhibited adequate accuracy in distinguishing between Aβ+ and Aβ- MCI (area under the curve: 0.788, 95% confidence interval: 0.703–0.872). Conclusions: The findings suggest that the Seoul CST may contribute to screening MCI patients who are likely to be Aβ+.