Ursane saponins from the stems of Firmiana simplex and their cytotoxic activity

Kyeong Wan Woo; Sang Un Choi; Ki Hyun Kim; Kang Ro Lee

doi:10.5935/0103-5053.20150113

Ursane saponins from the stems of Firmiana simplex and their cytotoxic activity

Kyeong Wan Woo
, Sang Un Choi
, Ki Hyun Kim
, Kang Ro Lee

Department of Pharmacy

Sungkyunkwan University
Korea Research Institute of Chemical Technology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Three new ursane triterpene saponins, together with twelve known ursane triterpenes were isolated from the stems of Firmiana simplex. The structures of the saponines were elucidated on the basis of spectroscopic and chemical methods. The cytotoxic activity of all compounds was evaluated in vitro against lung adenocarcinoma (A549), ovarian cancer (SK-OV-3), skin melanoma (SK-MEL-2), and colon cancer (HCT-15) human cell lines, using a sulforhodamine (SRB) assay. 23-Hydroxyursolic acid showed cytotoxicity against the tested cell lines with IC₅₀ values ranging from 11.96 to 14.11 μM.

Original language	English
Pages (from-to)	1450-1456
Number of pages	7
Journal	Journal of the Brazilian Chemical Society
Volume	26
Issue number	7
DOIs	https://doi.org/10.5935/0103-5053.20150113
State	Published - 1 Jul 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytotoxicity
Firmiana simplex
Sterculiaceae
Ursane triterpene saponin

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10.5935/0103-5053.20150113

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title = "Ursane saponins from the stems of Firmiana simplex and their cytotoxic activity",

abstract = "Three new ursane triterpene saponins, together with twelve known ursane triterpenes were isolated from the stems of Firmiana simplex. The structures of the saponines were elucidated on the basis of spectroscopic and chemical methods. The cytotoxic activity of all compounds was evaluated in vitro against lung adenocarcinoma (A549), ovarian cancer (SK-OV-3), skin melanoma (SK-MEL-2), and colon cancer (HCT-15) human cell lines, using a sulforhodamine (SRB) assay. 23-Hydroxyursolic acid showed cytotoxicity against the tested cell lines with IC50 values ranging from 11.96 to 14.11 μM.",

keywords = "Cytotoxicity, Firmiana simplex, Sterculiaceae, Ursane triterpene saponin",

author = "Woo, \{Kyeong Wan\} and Choi, \{Sang Un\} and Kim, \{Ki Hyun\} and Lee, \{Kang Ro\}",

note = "Publisher Copyright: {\textcopyright}2015 Sociedade Brasileira de Qu{\'i}mica.",

year = "2015",

month = jul,

day = "1",

doi = "10.5935/0103-5053.20150113",

language = "English",

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T1 - Ursane saponins from the stems of Firmiana simplex and their cytotoxic activity

AU - Woo, Kyeong Wan

AU - Choi, Sang Un

AU - Kim, Ki Hyun

AU - Lee, Kang Ro

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Three new ursane triterpene saponins, together with twelve known ursane triterpenes were isolated from the stems of Firmiana simplex. The structures of the saponines were elucidated on the basis of spectroscopic and chemical methods. The cytotoxic activity of all compounds was evaluated in vitro against lung adenocarcinoma (A549), ovarian cancer (SK-OV-3), skin melanoma (SK-MEL-2), and colon cancer (HCT-15) human cell lines, using a sulforhodamine (SRB) assay. 23-Hydroxyursolic acid showed cytotoxicity against the tested cell lines with IC50 values ranging from 11.96 to 14.11 μM.

AB - Three new ursane triterpene saponins, together with twelve known ursane triterpenes were isolated from the stems of Firmiana simplex. The structures of the saponines were elucidated on the basis of spectroscopic and chemical methods. The cytotoxic activity of all compounds was evaluated in vitro against lung adenocarcinoma (A549), ovarian cancer (SK-OV-3), skin melanoma (SK-MEL-2), and colon cancer (HCT-15) human cell lines, using a sulforhodamine (SRB) assay. 23-Hydroxyursolic acid showed cytotoxicity against the tested cell lines with IC50 values ranging from 11.96 to 14.11 μM.

KW - Cytotoxicity

KW - Firmiana simplex

KW - Sterculiaceae

KW - Ursane triterpene saponin

UR - https://www.scopus.com/pages/publications/84936877099

U2 - 10.5935/0103-5053.20150113

DO - 10.5935/0103-5053.20150113

M3 - Article

AN - SCOPUS:84936877099

SN - 0103-5053

VL - 26

SP - 1450

EP - 1456

JO - Journal of the Brazilian Chemical Society

JF - Journal of the Brazilian Chemical Society

IS - 7

ER -

Ursane saponins from the stems of Firmiana simplex and their cytotoxic activity

Abstract

UN SDGs

Keywords

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