Updated clinical practice guidelines for the management of adult diffuse gliomas

Tao Jiang; Do Hyun Nam; Zvi Ram; Wai sang Poo; Jiguang Wang; Damdindorj Boldbaatar; Ying Mao; Wenbin Ma; Qing Mao; Yongping You; Chuanlu Jiang; Xuejun Yang; Vinay Tergaonkar; Wei Zhang; Zheng Wang; Chunsheng Kang; Xiaoguang Qiu; Shaowu Li; Ling Chen; Xuejun Li; Zhixiong Liu; Hongmin Bai; Yu Yao; Shouwei Li; Anhua Wu; Yonggao Mou; Ke Sai; Guilin Li; Xinting Wei; Xianzhi Liu; Zhiwen Zhang; Yiwu Dai; Shengqing Lv; Liang Wang; Zhixiong Lin; Jun Dong; Guozheng Xu; Xiaodong Ma; Rutong Yu; Dezhi Kang; Yanhui Liu; Gang Li; Shizhong Zhang; Yan Qu; Yang Wang; Chuanbao Zhang; Baoshi Chen; Gan You; Yongzhi Wang; Yinyan Wang; Zhaoshi Bao; Xing Fan; Xing Liu; Zheng Zhao; Yiming Li; Zhiliang Wang; Guanzhang Li; Shengyu Fang; Yanwei Liu; Xia Shan; Yuqing Liu; Ruichao Chai; Huimin Hu; Jing Chen; Wei Yan; Jinquan Cai; Yu Wang

doi:10.1016/j.canlet.2025.218185

Updated clinical practice guidelines for the management of adult diffuse gliomas

Tao Jiang
, Do Hyun Nam
, Zvi Ram
, Wai sang Poo
, Jiguang Wang
, Damdindorj Boldbaatar
, Ying Mao
, Wenbin Ma
, Qing Mao
, Yongping You
, Chuanlu Jiang
, Xuejun Yang
, Vinay Tergaonkar
, Wei Zhang
, Zheng Wang
, Chunsheng Kang
, Xiaoguang Qiu
, Shaowu Li
, Ling Chen
, Xuejun Li

Zhixiong Liu, Hongmin Bai, Yu Yao, Shouwei Li, Anhua Wu, Yonggao Mou, Ke Sai, Guilin Li, Xinting Wei, Xianzhi Liu, Zhiwen Zhang, Yiwu Dai, Shengqing Lv, Liang Wang, Zhixiong Lin, Jun Dong, Guozheng Xu, Xiaodong Ma, Rutong Yu, Dezhi Kang, Yanhui Liu, Gang Li, Shizhong Zhang, Yan Qu, Yang Wang, Chuanbao Zhang, Baoshi Chen, Gan You, Yongzhi Wang, Yinyan Wang, Zhaoshi Bao, Xing Fan, Xing Liu, Zheng Zhao, Yiming Li, Zhiliang Wang, Guanzhang Li, Shengyu Fang, Yanwei Liu, Xia Shan, Yuqing Liu, Ruichao Chai, Huimin Hu, Jing Chen, Wei Yan, Jinquan Cai, Yu Wang

Department of Neurosurgery

Capital Medical University
Chinese Academy of Medical Sciences
Tel Aviv Sourasky Medical Center
Chinese University of Hong Kong
Hong Kong University of Science and Technology
Mongolian National University of Medical Sciences
Fudan University
Sichuan University
The First Affiliated Hospital of Nanjing Medical University
Harbin Medical University
Beijing Tsinghua Chang Gung Hospital
Agency for Science, Technology and Research, Singapore
Tianjin Medical University
General Hospital of People's Liberation Army
Central South University
General Hospital of Southern Theatre Command
China Medical University
Sun Yat-Sen University
Zhengzhou University
Army Medical University
Air Force Medical University
Soochow University
General Hospital of Central Theatre Command
Xuzhou Medical University
Fujian Medical University
Sichuan Medical University
Qilu Hospital of Shandong University
Southern Medical University
The Second Affiliated Hospital of PLA Air Force Military
The Second Affiliated Hospital of Harbin Medical University

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

It has been five years since the last version of the clinical practice guidelines for the management of adult diffuse gliomas was published by the Asian Glioma Genome Atlas (AGGA). Significant progress and revisions have occurred in the diagnosis and treatment of adult diffuse gliomas in recent years. In response to these updates, the joint guideline committee of the Chinese Glioma Cooperative Group (CGCG), the Society for Neuro-Oncology of China (SNO-China), and the Chinese Brain Cancer Association (CBCA) has revised the clinical practice guidelines. This updated guideline emphasizes molecular and pathological diagnostics, as well as the primary treatment modalities of surgery, radiotherapy, chemotherapy, and targeted therapy. Additionally, we have incorporated findings from recent clinical trials of new therapies to align with cutting-edge treatment strategies. This guideline is designed to serve as a practical resource for all professionals involved in managing adult diffuse glioma patients, while also providing valuable information for insurance companies and other institutions responsible for regulating cancer care costs in China and beyond.

Original language	English
Article number	218185
Journal	Cancer Letters
Volume	640
DOIs	https://doi.org/10.1016/j.canlet.2025.218185
State	Published - 1 Mar 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chemoradiation
Immune therapy
Molecular diagnostics
Surgery
Target therapy

Access to Document

10.1016/j.canlet.2025.218185

Cite this

Jiang, T., Nam, D. H., Ram, Z., Poo, W. S., Wang, J., Boldbaatar, D., Mao, Y., Ma, W., Mao, Q., You, Y., Jiang, C., Yang, X., Tergaonkar, V., Zhang, W., Wang, Z., Kang, C., Qiu, X., Li, S., Chen, L., ... Wang, Y. (2026). Updated clinical practice guidelines for the management of adult diffuse gliomas. Cancer Letters, 640, Article 218185. https://doi.org/10.1016/j.canlet.2025.218185

@article{f553ec87b38f4aeb84201b5b15a3770f,

title = "Updated clinical practice guidelines for the management of adult diffuse gliomas",

abstract = "It has been five years since the last version of the clinical practice guidelines for the management of adult diffuse gliomas was published by the Asian Glioma Genome Atlas (AGGA). Significant progress and revisions have occurred in the diagnosis and treatment of adult diffuse gliomas in recent years. In response to these updates, the joint guideline committee of the Chinese Glioma Cooperative Group (CGCG), the Society for Neuro-Oncology of China (SNO-China), and the Chinese Brain Cancer Association (CBCA) has revised the clinical practice guidelines. This updated guideline emphasizes molecular and pathological diagnostics, as well as the primary treatment modalities of surgery, radiotherapy, chemotherapy, and targeted therapy. Additionally, we have incorporated findings from recent clinical trials of new therapies to align with cutting-edge treatment strategies. This guideline is designed to serve as a practical resource for all professionals involved in managing adult diffuse glioma patients, while also providing valuable information for insurance companies and other institutions responsible for regulating cancer care costs in China and beyond.",

keywords = "Chemoradiation, Immune therapy, Molecular diagnostics, Surgery, Target therapy",

author = "Tao Jiang and Nam, \{Do Hyun\} and Zvi Ram and Poo, \{Wai sang\} and Jiguang Wang and Damdindorj Boldbaatar and Ying Mao and Wenbin Ma and Qing Mao and Yongping You and Chuanlu Jiang and Xuejun Yang and Vinay Tergaonkar and Wei Zhang and Zheng Wang and Chunsheng Kang and Xiaoguang Qiu and Shaowu Li and Ling Chen and Xuejun Li and Zhixiong Liu and Hongmin Bai and Yu Yao and Shouwei Li and Anhua Wu and Yonggao Mou and Ke Sai and Guilin Li and Xinting Wei and Xianzhi Liu and Zhiwen Zhang and Yiwu Dai and Shengqing Lv and Liang Wang and Zhixiong Lin and Jun Dong and Guozheng Xu and Xiaodong Ma and Rutong Yu and Dezhi Kang and Yanhui Liu and Gang Li and Shizhong Zhang and Yan Qu and Yang Wang and Chuanbao Zhang and Baoshi Chen and Gan You and Yongzhi Wang and Yinyan Wang and Zhaoshi Bao and Xing Fan and Xing Liu and Zheng Zhao and Yiming Li and Zhiliang Wang and Guanzhang Li and Shengyu Fang and Yanwei Liu and Xia Shan and Yuqing Liu and Ruichao Chai and Huimin Hu and Jing Chen and Wei Yan and Jinquan Cai and Yu Wang",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors.",

year = "2026",

month = mar,

day = "1",

doi = "10.1016/j.canlet.2025.218185",

language = "English",

volume = "640",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

}

Jiang, T, Nam, DH, Ram, Z, Poo, WS, Wang, J, Boldbaatar, D, Mao, Y, Ma, W, Mao, Q, You, Y, Jiang, C, Yang, X, Tergaonkar, V, Zhang, W, Wang, Z, Kang, C, Qiu, X, Li, S, Chen, L, Li, X, Liu, Z, Bai, H, Yao, Y, Li, S, Wu, A, Mou, Y, Sai, K, Li, G, Wei, X, Liu, X, Zhang, Z, Dai, Y, Lv, S, Wang, L, Lin, Z, Dong, J, Xu, G, Ma, X, Yu, R, Kang, D, Liu, Y, Li, G, Zhang, S, Qu, Y, Wang, Y, Zhang, C, Chen, B, You, G, Wang, Y, Wang, Y, Bao, Z, Fan, X, Liu, X, Zhao, Z, Li, Y, Wang, Z, Li, G, Fang, S, Liu, Y, Shan, X, Liu, Y, Chai, R, Hu, H, Chen, J, Yan, W, Cai, J & Wang, Y 2026, 'Updated clinical practice guidelines for the management of adult diffuse gliomas', Cancer Letters, vol. 640, 218185. https://doi.org/10.1016/j.canlet.2025.218185

TY - JOUR

T1 - Updated clinical practice guidelines for the management of adult diffuse gliomas

AU - Jiang, Tao

AU - Nam, Do Hyun

AU - Ram, Zvi

AU - Poo, Wai sang

AU - Wang, Jiguang

AU - Boldbaatar, Damdindorj

AU - Mao, Ying

AU - Ma, Wenbin

AU - Mao, Qing

AU - You, Yongping

AU - Jiang, Chuanlu

AU - Yang, Xuejun

AU - Tergaonkar, Vinay

AU - Zhang, Wei

AU - Wang, Zheng

AU - Kang, Chunsheng

AU - Qiu, Xiaoguang

AU - Li, Shaowu

AU - Chen, Ling

AU - Li, Xuejun

AU - Liu, Zhixiong

AU - Bai, Hongmin

AU - Yao, Yu

AU - Li, Shouwei

AU - Wu, Anhua

AU - Mou, Yonggao

AU - Sai, Ke

AU - Li, Guilin

AU - Wei, Xinting

AU - Liu, Xianzhi

AU - Zhang, Zhiwen

AU - Dai, Yiwu

AU - Lv, Shengqing

AU - Wang, Liang

AU - Lin, Zhixiong

AU - Dong, Jun

AU - Xu, Guozheng

AU - Ma, Xiaodong

AU - Yu, Rutong

AU - Kang, Dezhi

AU - Liu, Yanhui

AU - Li, Gang

AU - Zhang, Shizhong

AU - Qu, Yan

AU - Wang, Yang

AU - Zhang, Chuanbao

AU - Chen, Baoshi

AU - You, Gan

AU - Wang, Yongzhi

AU - Wang, Yinyan

AU - Bao, Zhaoshi

AU - Fan, Xing

AU - Liu, Xing

AU - Zhao, Zheng

AU - Li, Yiming

AU - Wang, Zhiliang

AU - Li, Guanzhang

AU - Fang, Shengyu

AU - Liu, Yanwei

AU - Shan, Xia

AU - Liu, Yuqing

AU - Chai, Ruichao

AU - Hu, Huimin

AU - Chen, Jing

AU - Yan, Wei

AU - Cai, Jinquan

AU - Wang, Yu

PY - 2026/3/1

Y1 - 2026/3/1

N2 - It has been five years since the last version of the clinical practice guidelines for the management of adult diffuse gliomas was published by the Asian Glioma Genome Atlas (AGGA). Significant progress and revisions have occurred in the diagnosis and treatment of adult diffuse gliomas in recent years. In response to these updates, the joint guideline committee of the Chinese Glioma Cooperative Group (CGCG), the Society for Neuro-Oncology of China (SNO-China), and the Chinese Brain Cancer Association (CBCA) has revised the clinical practice guidelines. This updated guideline emphasizes molecular and pathological diagnostics, as well as the primary treatment modalities of surgery, radiotherapy, chemotherapy, and targeted therapy. Additionally, we have incorporated findings from recent clinical trials of new therapies to align with cutting-edge treatment strategies. This guideline is designed to serve as a practical resource for all professionals involved in managing adult diffuse glioma patients, while also providing valuable information for insurance companies and other institutions responsible for regulating cancer care costs in China and beyond.

AB - It has been five years since the last version of the clinical practice guidelines for the management of adult diffuse gliomas was published by the Asian Glioma Genome Atlas (AGGA). Significant progress and revisions have occurred in the diagnosis and treatment of adult diffuse gliomas in recent years. In response to these updates, the joint guideline committee of the Chinese Glioma Cooperative Group (CGCG), the Society for Neuro-Oncology of China (SNO-China), and the Chinese Brain Cancer Association (CBCA) has revised the clinical practice guidelines. This updated guideline emphasizes molecular and pathological diagnostics, as well as the primary treatment modalities of surgery, radiotherapy, chemotherapy, and targeted therapy. Additionally, we have incorporated findings from recent clinical trials of new therapies to align with cutting-edge treatment strategies. This guideline is designed to serve as a practical resource for all professionals involved in managing adult diffuse glioma patients, while also providing valuable information for insurance companies and other institutions responsible for regulating cancer care costs in China and beyond.

KW - Chemoradiation

KW - Immune therapy

KW - Molecular diagnostics

KW - Surgery

KW - Target therapy

UR - https://www.scopus.com/pages/publications/105027941004

U2 - 10.1016/j.canlet.2025.218185

DO - 10.1016/j.canlet.2025.218185

M3 - Review article

C2 - 41338443

AN - SCOPUS:105027941004

SN - 0304-3835

VL - 640

JO - Cancer Letters

JF - Cancer Letters

M1 - 218185

ER -

Updated clinical practice guidelines for the management of adult diffuse gliomas

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this