Two new phenolic compounds from the white flower of Impatiens balsamina

Chung Sub Kim; Lalita Subedi; Sun Yeou Kim; Sang Un Choi; Sang Zin Choi; Mi Won Son; Ki Hyun Kim; Kang Ro Lee

doi:10.1016/j.phytol.2015.10.014

Two new phenolic compounds from the white flower of Impatiens balsamina

Chung Sub Kim, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Sang Zin Choi, Mi Won Son, Ki Hyun Kim, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

During the course of our continuing search for biologically active compounds from Korean medicinal sources, we investigated the white flower of Impatiens balsamina. From the MeOH extract, two new phenolic compounds (1-2) containing a nitrile group and eleven known phenolic compounds (3-13) were isolated. The chemical structures of new compounds (1-2) were determined through NMR, HRMS, and CD data. We tested the isolated compounds (1-13) for their cytotoxic activities by determining their inhibitory effects on human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay. We also investigated their neuroprotective activity by determining their effects on nerve growth factor (NGF) secretion in C6 cells, and anti-neuroinflammatory activity by measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV-2 cells.

Original language	English
Pages (from-to)	215-220
Number of pages	6
Journal	Phytochemistry Letters
Volume	14
DOIs	https://doi.org/10.1016/j.phytol.2015.10.014
State	Published - 1 Dec 2015

Keywords

Anti-neuroinflammation
Balsamineaceae
Cytotoxicity
Impatiens balsamina
Neuroprotection
Phenolic compounds

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10.1016/j.phytol.2015.10.014

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title = "Two new phenolic compounds from the white flower of Impatiens balsamina",

abstract = "During the course of our continuing search for biologically active compounds from Korean medicinal sources, we investigated the white flower of Impatiens balsamina. From the MeOH extract, two new phenolic compounds (1-2) containing a nitrile group and eleven known phenolic compounds (3-13) were isolated. The chemical structures of new compounds (1-2) were determined through NMR, HRMS, and CD data. We tested the isolated compounds (1-13) for their cytotoxic activities by determining their inhibitory effects on human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay. We also investigated their neuroprotective activity by determining their effects on nerve growth factor (NGF) secretion in C6 cells, and anti-neuroinflammatory activity by measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV-2 cells.",

keywords = "Anti-neuroinflammation, Balsamineaceae, Cytotoxicity, Impatiens balsamina, Neuroprotection, Phenolic compounds",

author = "Kim, \{Chung Sub\} and Lalita Subedi and Kim, \{Sun Yeou\} and Choi, \{Sang Un\} and Choi, \{Sang Zin\} and Son, \{Mi Won\} and Kim, \{Ki Hyun\} and Lee, \{Kang Ro\}",

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doi = "10.1016/j.phytol.2015.10.014",

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journal = "Phytochemistry Letters",

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T1 - Two new phenolic compounds from the white flower of Impatiens balsamina

AU - Kim, Chung Sub

AU - Subedi, Lalita

AU - Kim, Sun Yeou

AU - Choi, Sang Un

AU - Choi, Sang Zin

AU - Son, Mi Won

AU - Kim, Ki Hyun

AU - Lee, Kang Ro

PY - 2015/12/1

Y1 - 2015/12/1

N2 - During the course of our continuing search for biologically active compounds from Korean medicinal sources, we investigated the white flower of Impatiens balsamina. From the MeOH extract, two new phenolic compounds (1-2) containing a nitrile group and eleven known phenolic compounds (3-13) were isolated. The chemical structures of new compounds (1-2) were determined through NMR, HRMS, and CD data. We tested the isolated compounds (1-13) for their cytotoxic activities by determining their inhibitory effects on human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay. We also investigated their neuroprotective activity by determining their effects on nerve growth factor (NGF) secretion in C6 cells, and anti-neuroinflammatory activity by measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV-2 cells.

AB - During the course of our continuing search for biologically active compounds from Korean medicinal sources, we investigated the white flower of Impatiens balsamina. From the MeOH extract, two new phenolic compounds (1-2) containing a nitrile group and eleven known phenolic compounds (3-13) were isolated. The chemical structures of new compounds (1-2) were determined through NMR, HRMS, and CD data. We tested the isolated compounds (1-13) for their cytotoxic activities by determining their inhibitory effects on human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay. We also investigated their neuroprotective activity by determining their effects on nerve growth factor (NGF) secretion in C6 cells, and anti-neuroinflammatory activity by measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV-2 cells.

KW - Anti-neuroinflammation

KW - Balsamineaceae

KW - Cytotoxicity

KW - Impatiens balsamina

KW - Neuroprotection

KW - Phenolic compounds

UR - https://www.scopus.com/pages/publications/84946150466

U2 - 10.1016/j.phytol.2015.10.014

DO - 10.1016/j.phytol.2015.10.014

M3 - Article

AN - SCOPUS:84946150466

SN - 1874-3900

VL - 14

SP - 215

EP - 220

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Two new phenolic compounds from the white flower of Impatiens balsamina

Abstract

Keywords

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