Tumor microenvironment on a chip: The progress and future perspective

Jungho Ahn; Yoshitaka J. Sei; Noo Li Jeon; Yongtae Kim

doi:10.3390/bioengineering4030064

Tumor microenvironment on a chip: The progress and future perspective

Jungho Ahn
, Yoshitaka J. Sei
, Noo Li Jeon
, Yongtae Kim

Georgia Institute of Technology
Seoul National University

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.

Original language	English
Article number	64
Journal	Bioengineering
Volume	4
Issue number	3
DOIs	https://doi.org/10.3390/bioengineering4030064
State	Published - Sep 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Drug screening
In vitro disease models
Microfluidics
Nanomedicine
Organ-on-a-chip
Tumor microenvironment

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10.3390/bioengineering4030064

Cite this

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title = "Tumor microenvironment on a chip: The progress and future perspective",

abstract = "Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.",

keywords = "Drug screening, In vitro disease models, Microfluidics, Nanomedicine, Organ-on-a-chip, Tumor microenvironment",

author = "Jungho Ahn and Sei, \{Yoshitaka J.\} and Jeon, \{Noo Li\} and Yongtae Kim",

note = "Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2017",

month = sep,

doi = "10.3390/bioengineering4030064",

language = "English",

volume = "4",

journal = "Bioengineering",

issn = "2306-5354",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Tumor microenvironment on a chip

T2 - The progress and future perspective

AU - Ahn, Jungho

AU - Sei, Yoshitaka J.

AU - Jeon, Noo Li

AU - Kim, Yongtae

PY - 2017/9

Y1 - 2017/9

N2 - Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.

AB - Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.

KW - Drug screening

KW - In vitro disease models

KW - Microfluidics

KW - Nanomedicine

KW - Organ-on-a-chip

KW - Tumor microenvironment

UR - https://www.scopus.com/pages/publications/85042222741

U2 - 10.3390/bioengineering4030064

DO - 10.3390/bioengineering4030064

M3 - Review article

AN - SCOPUS:85042222741

SN - 2306-5354

VL - 4

JO - Bioengineering

JF - Bioengineering

IS - 3

M1 - 64

ER -

Tumor microenvironment on a chip: The progress and future perspective

Abstract

UN SDGs

Keywords

Access to Document

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