Triterpenoids from the leaves of Abies koreana and their biological activities

Dong Jun Lee; Seong Min Hong; Da Hye Yoon; Song Lim Ham; Jonghwan Kim; Sun Yeou Kim; Sang Un Choi; Chung Sub Kim; Kang Ro Lee

doi:10.1016/j.phytochem.2023.113594

Triterpenoids from the leaves of Abies koreana and their biological activities

Dong Jun Lee
, Seong Min Hong
, Da Hye Yoon
, Song Lim Ham
, Jonghwan Kim
, Sun Yeou Kim
, Sang Un Choi
, Chung Sub Kim
, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Seven undescribed triterpenoids, abikoranes A–G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC₅₀ 0.89–9.62 μM, inhibited lipopolysaccharide-stimulated nitric oxide production with IC₅₀ values of 11.57–15.16 μM, and exhibited significant nerve growth factor release effect (192.54 ± 12.33%) from C6 glioma cells.

Original language	English
Article number	113594
Journal	Phytochemistry
Volume	208
DOIs	https://doi.org/10.1016/j.phytochem.2023.113594
State	Published - Apr 2023

Keywords

Abies koreana
Anti-neuroinflammation
Cytotoxic
Neurotrophic
Pinaceae
Triterpenoid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2023.113594

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@article{eefeda5bc38348ebba96e1a617c2a80a,

title = "Triterpenoids from the leaves of Abies koreana and their biological activities",

abstract = "Seven undescribed triterpenoids, abikoranes A–G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC50 0.89–9.62 μM, inhibited lipopolysaccharide-stimulated nitric oxide production with IC50 values of 11.57–15.16 μM, and exhibited significant nerve growth factor release effect (192.54 ± 12.33\%) from C6 glioma cells.",

keywords = "Abies koreana, Anti-neuroinflammation, Cytotoxic, Neurotrophic, Pinaceae, Triterpenoid",

author = "Lee, \{Dong Jun\} and Hong, \{Seong Min\} and Yoon, \{Da Hye\} and Ham, \{Song Lim\} and Jonghwan Kim and Kim, \{Sun Yeou\} and Choi, \{Sang Un\} and Kim, \{Chung Sub\} and Lee, \{Kang Ro\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = apr,

doi = "10.1016/j.phytochem.2023.113594",

language = "English",

volume = "208",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Triterpenoids from the leaves of Abies koreana and their biological activities

AU - Lee, Dong Jun

AU - Hong, Seong Min

AU - Yoon, Da Hye

AU - Ham, Song Lim

AU - Kim, Jonghwan

AU - Kim, Sun Yeou

AU - Choi, Sang Un

AU - Kim, Chung Sub

AU - Lee, Kang Ro

PY - 2023/4

Y1 - 2023/4

N2 - Seven undescribed triterpenoids, abikoranes A–G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC50 0.89–9.62 μM, inhibited lipopolysaccharide-stimulated nitric oxide production with IC50 values of 11.57–15.16 μM, and exhibited significant nerve growth factor release effect (192.54 ± 12.33%) from C6 glioma cells.

AB - Seven undescribed triterpenoids, abikoranes A–G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC50 0.89–9.62 μM, inhibited lipopolysaccharide-stimulated nitric oxide production with IC50 values of 11.57–15.16 μM, and exhibited significant nerve growth factor release effect (192.54 ± 12.33%) from C6 glioma cells.

KW - Abies koreana

KW - Anti-neuroinflammation

KW - Cytotoxic

KW - Neurotrophic

KW - Pinaceae

KW - Triterpenoid

UR - https://www.scopus.com/pages/publications/85147686007

U2 - 10.1016/j.phytochem.2023.113594

DO - 10.1016/j.phytochem.2023.113594

M3 - Article

C2 - 36738908

AN - SCOPUS:85147686007

SN - 0031-9422

VL - 208

JO - Phytochemistry

JF - Phytochemistry

M1 - 113594

ER -

Triterpenoids from the leaves of Abies koreana and their biological activities

Abstract

Keywords

UN SDGs

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