Triterpenes from perilla frutescens var. acuta and their cytotoxic activity

Kyeong Wan Woo; Ji Young Han; Sang Un Choi; Ki Hyun Kim; Kang Ro Lee

Triterpenes from perilla frutescens var. acuta and their cytotoxic activity

Kyeong Wan Woo
, Ji Young Han
, Sang Un Choi
, Ki Hyun Kim
, Kang Ro Lee

Department of Pharmacy

Sungkyunkwan University
Korea Research Institute of Chemical Technology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Nine triterpenes were isolated from the petroleum ether and MeOH extract of Perilla frutescens var. acuta leaves. Their structures were determined to be arjunic acid (1), maslinic acid (2), oleanolic acid (3), euscaphic acid (4), tormentic acid (5), 3-O-trans-p-coumaroyltormentic acid (6), 28-formyloxy-3β-hydroxy-urs-12-ene (7), ursolic acid (8), and corosolic acid (9) by spectroscopic methods. The compounds 1, 2, 4, 6, and 7were isolated for the first time from this plant and the Genus Labiatae. The isolated compounds (1-9) were tested for cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro using a Sulforhodamin B bioassay.

Original language	English
Pages (from-to)	71-75
Number of pages	5
Journal	Natural Product Sciences
Volume	20
Issue number	2
State	Published - 2014

Keywords

Cytotoxicity
Labiatae
Perilla frutescens var. acuta
Triterpene

Cite this

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title = "Triterpenes from perilla frutescens var. acuta and their cytotoxic activity",

abstract = "Nine triterpenes were isolated from the petroleum ether and MeOH extract of Perilla frutescens var. acuta leaves. Their structures were determined to be arjunic acid (1), maslinic acid (2), oleanolic acid (3), euscaphic acid (4), tormentic acid (5), 3-O-trans-p-coumaroyltormentic acid (6), 28-formyloxy-3β-hydroxy-urs-12-ene (7), ursolic acid (8), and corosolic acid (9) by spectroscopic methods. The compounds 1, 2, 4, 6, and 7were isolated for the first time from this plant and the Genus Labiatae. The isolated compounds (1-9) were tested for cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro using a Sulforhodamin B bioassay.",

keywords = "Cytotoxicity, Labiatae, Perilla frutescens var. acuta, Triterpene",

author = "Woo, \{Kyeong Wan\} and Han, \{Ji Young\} and Choi, \{Sang Un\} and Kim, \{Ki Hyun\} and Lee, \{Kang Ro\}",

year = "2014",

language = "English",

volume = "20",

pages = "71--75",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

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TY - JOUR

T1 - Triterpenes from perilla frutescens var. acuta and their cytotoxic activity

AU - Woo, Kyeong Wan

AU - Han, Ji Young

AU - Choi, Sang Un

AU - Kim, Ki Hyun

AU - Lee, Kang Ro

PY - 2014

Y1 - 2014

N2 - Nine triterpenes were isolated from the petroleum ether and MeOH extract of Perilla frutescens var. acuta leaves. Their structures were determined to be arjunic acid (1), maslinic acid (2), oleanolic acid (3), euscaphic acid (4), tormentic acid (5), 3-O-trans-p-coumaroyltormentic acid (6), 28-formyloxy-3β-hydroxy-urs-12-ene (7), ursolic acid (8), and corosolic acid (9) by spectroscopic methods. The compounds 1, 2, 4, 6, and 7were isolated for the first time from this plant and the Genus Labiatae. The isolated compounds (1-9) were tested for cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro using a Sulforhodamin B bioassay.

AB - Nine triterpenes were isolated from the petroleum ether and MeOH extract of Perilla frutescens var. acuta leaves. Their structures were determined to be arjunic acid (1), maslinic acid (2), oleanolic acid (3), euscaphic acid (4), tormentic acid (5), 3-O-trans-p-coumaroyltormentic acid (6), 28-formyloxy-3β-hydroxy-urs-12-ene (7), ursolic acid (8), and corosolic acid (9) by spectroscopic methods. The compounds 1, 2, 4, 6, and 7were isolated for the first time from this plant and the Genus Labiatae. The isolated compounds (1-9) were tested for cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro using a Sulforhodamin B bioassay.

KW - Cytotoxicity

KW - Labiatae

KW - Perilla frutescens var. acuta

KW - Triterpene

UR - https://www.scopus.com/pages/publications/84908501470

M3 - Article

AN - SCOPUS:84908501470

SN - 1226-3907

VL - 20

SP - 71

EP - 75

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 2

ER -

Triterpenes from perilla frutescens var. acuta and their cytotoxic activity

Abstract

Keywords

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