Transcriptional mimicry by tumor-associated stroma

Hoon Kim; Roel G.W. Verhaak

doi:10.1038/ng.3255

Transcriptional mimicry by tumor-associated stroma

Hoon Kim, Roel G.W. Verhaak

University of Texas MD Anderson Cancer Center

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.

Original language	English
Pages (from-to)	307-309
Number of pages	3
Journal	Nature Genetics
Volume	47
Issue number	4
DOIs	https://doi.org/10.1038/ng.3255
State	Published - 28 Apr 2015
Externally published	Yes

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10.1038/ng.3255

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title = "Transcriptional mimicry by tumor-associated stroma",

abstract = "Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.",

author = "Hoon Kim and Verhaak, \{Roel G.W.\}",

year = "2015",

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T1 - Transcriptional mimicry by tumor-associated stroma

AU - Kim, Hoon

AU - Verhaak, Roel G.W.

PY - 2015/4/28

Y1 - 2015/4/28

N2 - Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.

AB - Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.

UR - https://www.scopus.com/pages/publications/84925699872

U2 - 10.1038/ng.3255

DO - 10.1038/ng.3255

M3 - Short survey

C2 - 25814306

AN - SCOPUS:84925699872

SN - 1061-4036

VL - 47

SP - 307

EP - 309

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

Transcriptional mimicry by tumor-associated stroma

Abstract

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