TY - JOUR
T1 - Toxicity of mixture of polyethylene microplastics and Up Grade® pesticide on Oreochromis niloticus juvenile
T2 - I. Hemato-biochemical and histopathological alterations
AU - Mohamed, Ibrahim A.
AU - Soliman, Hamdy A.M.
AU - Hana, Mervat
AU - Lee, Jae Seong
AU - Sayed, Alaa El Din H.
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/8
Y1 - 2023/8
N2 - Acute toxicity experiments were conducted to determine the lethal concentration 50 (LC50) of the Up Grade®46% SL for Oreochromis niloticus. Our results showed that the 96-h LC50 value of UPGR for O. niloticus was 29.16 mg L-1. To study hemato-biochemical effects, fish were exposed for 15 days to individual UPGR at 2.916 mg L-1, individual polyethylene microplastics (PE-MPs) at 10 mg L-1, and to their combinations UPGR+PE-MPs. UPGR exposure induced significant decrease in account of red blood cells (RBCs) and white blood cells (WBCs), platelets, monocytes, neutrophils, eosinophils, and the concentrations of hemoglobin (Hb), hematocrit (Hct), and mean corpuscular hemoglobin concentration (MCHC) than other treatments, compared to the control group. Sub-acute UPGR exposure significantly increase lymphocytes, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH), compared to the control group. In conclusion, UPGR and PE-MPs displayed antagonistic toxic effects due to maybe the sorption of UPGR onto PE-MPs.
AB - Acute toxicity experiments were conducted to determine the lethal concentration 50 (LC50) of the Up Grade®46% SL for Oreochromis niloticus. Our results showed that the 96-h LC50 value of UPGR for O. niloticus was 29.16 mg L-1. To study hemato-biochemical effects, fish were exposed for 15 days to individual UPGR at 2.916 mg L-1, individual polyethylene microplastics (PE-MPs) at 10 mg L-1, and to their combinations UPGR+PE-MPs. UPGR exposure induced significant decrease in account of red blood cells (RBCs) and white blood cells (WBCs), platelets, monocytes, neutrophils, eosinophils, and the concentrations of hemoglobin (Hb), hematocrit (Hct), and mean corpuscular hemoglobin concentration (MCHC) than other treatments, compared to the control group. Sub-acute UPGR exposure significantly increase lymphocytes, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH), compared to the control group. In conclusion, UPGR and PE-MPs displayed antagonistic toxic effects due to maybe the sorption of UPGR onto PE-MPs.
KW - Biomarkers
KW - Blood cells
KW - Herbicide
KW - Microplastics
KW - Nile tilapia
UR - https://www.scopus.com/pages/publications/85164451811
U2 - 10.1016/j.etap.2023.104213
DO - 10.1016/j.etap.2023.104213
M3 - Article
C2 - 37422028
AN - SCOPUS:85164451811
SN - 1382-6689
VL - 101
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
M1 - 104213
ER -