Abstract
Bioreactor systems in tissue engineering applications provide various types of stimulation to mimic the tissues in vitro and in vivo. Various bioreactors have been designed to induce high cellular activities, including initial cell attachment, cell growth, and differentiation. Although cell-stimulation processes exert mostly positive effects on cellular responses, in some cases such stimulation can also have a negative effect on cultured cells. In this review, we discuss various types of bioreactor and the positive and negative effects of stimulation (physical, chemical, and electrical) on various cultured cell types.
| Original language | English |
|---|---|
| Pages (from-to) | 935-948 |
| Number of pages | 14 |
| Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
| Volume | 103 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 May 2015 |
Keywords
- cell-material interactions
- electrical stimulation
- tissue engineering
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