Three new fatty acid esters from the mushroom Boletus pseudocalopus

Ki Hyun Kim; Sang Un Choi; Kang Ro Lee

doi:10.1007/s11745-012-3657-2

Three new fatty acid esters from the mushroom Boletus pseudocalopus

Ki Hyun Kim, Sang Un Choi, Kang Ro Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A bioassay-guided fractionation and chemical investigation of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus resulted in the identification of three new fatty acid esters, named calopusins A-C (1-3), along with two known fatty acid methyl esters (4-5). These new compounds are structurally unique fatty acid esters with a 2,3-butanediol moiety. Their structures were elucidated through 1D- and 2D-NMR spectroscopic data and GC-MS analysis as well as a modified Mosher's method. The new compounds 1-3 showed significant inhibitory activity against the proliferation of the tested cancer cell lines with IC⁵⁰ values in the range 2.77-12.51 μM.

Original language	English
Pages (from-to)	593-599
Number of pages	7
Journal	Lipids
Volume	47
Issue number	6
DOIs	https://doi.org/10.1007/s11745-012-3657-2
State	Published - Jun 2012

Keywords

Boletaceae
Boletus pseudocalopus
Cytotoxicity
Fatty acid esters

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11745-012-3657-2

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title = "Three new fatty acid esters from the mushroom Boletus pseudocalopus",

abstract = "A bioassay-guided fractionation and chemical investigation of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus resulted in the identification of three new fatty acid esters, named calopusins A-C (1-3), along with two known fatty acid methyl esters (4-5). These new compounds are structurally unique fatty acid esters with a 2,3-butanediol moiety. Their structures were elucidated through 1D- and 2D-NMR spectroscopic data and GC-MS analysis as well as a modified Mosher's method. The new compounds 1-3 showed significant inhibitory activity against the proliferation of the tested cancer cell lines with IC50 values in the range 2.77-12.51 μM.",

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doi = "10.1007/s11745-012-3657-2",

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AU - Kim, Ki Hyun

AU - Choi, Sang Un

AU - Lee, Kang Ro

PY - 2012/6

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N2 - A bioassay-guided fractionation and chemical investigation of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus resulted in the identification of three new fatty acid esters, named calopusins A-C (1-3), along with two known fatty acid methyl esters (4-5). These new compounds are structurally unique fatty acid esters with a 2,3-butanediol moiety. Their structures were elucidated through 1D- and 2D-NMR spectroscopic data and GC-MS analysis as well as a modified Mosher's method. The new compounds 1-3 showed significant inhibitory activity against the proliferation of the tested cancer cell lines with IC50 values in the range 2.77-12.51 μM.

AB - A bioassay-guided fractionation and chemical investigation of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus resulted in the identification of three new fatty acid esters, named calopusins A-C (1-3), along with two known fatty acid methyl esters (4-5). These new compounds are structurally unique fatty acid esters with a 2,3-butanediol moiety. Their structures were elucidated through 1D- and 2D-NMR spectroscopic data and GC-MS analysis as well as a modified Mosher's method. The new compounds 1-3 showed significant inhibitory activity against the proliferation of the tested cancer cell lines with IC50 values in the range 2.77-12.51 μM.

KW - Boletaceae

KW - Boletus pseudocalopus

KW - Cytotoxicity

KW - Fatty acid esters

UR - https://www.scopus.com/pages/publications/84863424612

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DO - 10.1007/s11745-012-3657-2

M3 - Article

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AN - SCOPUS:84863424612

SN - 0024-4201

VL - 47

SP - 593

EP - 599

JO - Lipids

JF - Lipids

IS - 6

ER -

Three new fatty acid esters from the mushroom Boletus pseudocalopus

Abstract

Keywords

UN SDGs

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