Thione-Directed C-H Amidation of Chromone Analogues with Dioxazolones under Rh(III) Catalysis

Sulfur-containing organic molecules are recognized as promising candidates for catalytic C-H functionalization and medicinal chemistry owing to the exceptional ability of the sulfur atom to bind to transition metals and target enzymes. In this study, we report the Rh(III)-catalyzed thione-directed C-H amidation of various thiochromone analogues derived from flavones, isoflavones, and xanthones. Post-transformations of C5-amidated thiochromone products were investigated, and a series of mechanistic studies were performed.