The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell-Derived Pressures

David G. Russell; Wonsik Lee; Shumin Tan; Neelima Sukumar; Maria Podinovskaia; Ruth J. Fahey; Brian C. VanderVen

doi:10.1128/9781555818845.ch35

The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell-Derived Pressures

David G. Russell
, Wonsik Lee
, Shumin Tan
, Neelima Sukumar
, Maria Podinovskaia
, Ruth J. Fahey
, Brian C. VanderVen

Cornell University College of Veterinary Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The macrophage plays host to Mycobacterium tuberculosis for much of the duration of its infection cycle (1, 2). And while the bacterium is not an obligate intracellular pathogen, the macrophage has undoubtedly played a dominant role in shaping the genome of M. tuberculosis.

Original language	English
Title of host publication	Molecular Genetics of Mycobacteria
Publisher	wiley
Pages	727-745
Number of pages	19
ISBN (Electronic)	9781683671008
ISBN (Print)	9781555818838
DOIs	https://doi.org/10.1128/9781555818845.ch35
State	Published - 22 Oct 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Host cells
Mycobacterium senses
Mycobacterium tuberculosis genome
Transcriptional profiling
Transitional physiological
Transposon insertion-site mapping

Access to Document

10.1128/9781555818845.ch35

Cite this

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abstract = "The macrophage plays host to Mycobacterium tuberculosis for much of the duration of its infection cycle (1, 2). And while the bacterium is not an obligate intracellular pathogen, the macrophage has undoubtedly played a dominant role in shaping the genome of M. tuberculosis.",

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author = "Russell, \{David G.\} and Wonsik Lee and Shumin Tan and Neelima Sukumar and Maria Podinovskaia and Fahey, \{Ruth J.\} and VanderVen, \{Brian C.\}",

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AU - Podinovskaia, Maria

AU - Fahey, Ruth J.

AU - VanderVen, Brian C.

PY - 2015/10/22

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KW - Mycobacterium tuberculosis genome

KW - Transcriptional profiling

KW - Transitional physiological

KW - Transposon insertion-site mapping

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M3 - Chapter

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The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell-Derived Pressures

Abstract

UN SDGs

Keywords

Access to Document

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