Abstract
Self-regulating resident macrophages inhabit all mammalian organs throughout all phases of life. In addition to functions in inflammation and immunity, macrophages play a significant role in the maintenance of tissue homeostasis in response to various environmental stimuli. In this chapter, we review the functions of macrophages in mediating homeostasis, in development, and in the immune system and outline the impact of macrophage heterogeneity on tissue-specific homeostasis. Furthermore, we discuss the epigenetic regulation of macrophages and how macrophages mediate homeostatic processes in tissue integrity and prevent the development of chronic inflammatory diseases. Finally, we summarize the current developments in therapeutic approaches that target host defense modulators.
| Original language | English |
|---|---|
| Title of host publication | Recent Advancements in Microbial Diversity |
| Subtitle of host publication | Macrophages and their Role in Inflammation |
| Publisher | Elsevier |
| Pages | 419-446 |
| Number of pages | 28 |
| ISBN (Electronic) | 9780128223680 |
| ISBN (Print) | 9780128223697 |
| DOIs | |
| State | Published - 1 Jan 2022 |
Keywords
- epigenetic
- homeostasis
- immune response
- inflammation
- Macrophage
Fingerprint
Dive into the research topics of 'The roles of macrophages in mediating the homeostatic process'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver