TY - JOUR
T1 - The relationship between heart rate recovery and brain natruretic peptide in patients with chest discomfort
T2 - A study for relationship between heart rate recovery and pre-exercise, post-exercise levels of brain natruretic peptide in patients with normal systolic function and chest discomfort
AU - Lee, Jae Eun
AU - Kim, Bum Soo
AU - Park, Wan
AU - Huh, Jung Kwon
AU - Kim, Byung Jin
AU - Sung, Ki Chul
AU - Kang, Jin Ho
AU - Lee, Man Ho
AU - Park, Jung Ro
PY - 2010/4
Y1 - 2010/4
N2 - Background and Objectives: The Correlation between brain natruretic peptide (BNP) level and cardiac autonomic function has been studied in type 2 diabetic patients. However, there is limited data from patients with normal systolic function. We evaluated the association between heart rate recovery (HRR) representing autonomic dysfunction and three plasma BNP levels: pre-exercise, post-exercise, and change during exercise in patients with normal systolic function. Subjects and Methods: Subjects included 105 patients with chest pain and normal systolic function. HRR was defined as the difference between the peak heart rate and the rate measured two minutes after completion of a treadmill exercise test. We measured plasma BNP levels before exercise, 5 minutes after completion of exercise, and during exercise (absolute value of difference between pre- and post-exercise BNP levels). Results: Patients with abnormal HRR values (≤24 beats for the first 2 minutes of HRR) had lower high-density lipoprotein, lower peak heart rates, and higher pre- and post-exercise BNP levels than patients with normal HRR values. The patients with coronary artery disease (CAD) had abnormal HRR. However, no significant differences were found between the two groups in terms of history of hypertension (HTN), diabetes, and peak systolic blood pressure (SBP) and diastolic blood pressure (DBP). HRR was significantly associated with pre-exercise BNP (r=-0.36, p=0.004) and post-exercise BNP (r=-0.27, p=0.006), but not BNP changes. Further, pre-exercise BNP levels showed a greater association with HRR than post-exercise BNP levels. Conclusion: HRR is independently associated with pre-exercise and post-exercise BNP levels, even in patients with normal systolic function.
AB - Background and Objectives: The Correlation between brain natruretic peptide (BNP) level and cardiac autonomic function has been studied in type 2 diabetic patients. However, there is limited data from patients with normal systolic function. We evaluated the association between heart rate recovery (HRR) representing autonomic dysfunction and three plasma BNP levels: pre-exercise, post-exercise, and change during exercise in patients with normal systolic function. Subjects and Methods: Subjects included 105 patients with chest pain and normal systolic function. HRR was defined as the difference between the peak heart rate and the rate measured two minutes after completion of a treadmill exercise test. We measured plasma BNP levels before exercise, 5 minutes after completion of exercise, and during exercise (absolute value of difference between pre- and post-exercise BNP levels). Results: Patients with abnormal HRR values (≤24 beats for the first 2 minutes of HRR) had lower high-density lipoprotein, lower peak heart rates, and higher pre- and post-exercise BNP levels than patients with normal HRR values. The patients with coronary artery disease (CAD) had abnormal HRR. However, no significant differences were found between the two groups in terms of history of hypertension (HTN), diabetes, and peak systolic blood pressure (SBP) and diastolic blood pressure (DBP). HRR was significantly associated with pre-exercise BNP (r=-0.36, p=0.004) and post-exercise BNP (r=-0.27, p=0.006), but not BNP changes. Further, pre-exercise BNP levels showed a greater association with HRR than post-exercise BNP levels. Conclusion: HRR is independently associated with pre-exercise and post-exercise BNP levels, even in patients with normal systolic function.
KW - Autonomic dysfunction
KW - Brain
KW - Heart rate
KW - Natruretic peptide
KW - Ventricular ejection fraction
UR - https://www.scopus.com/pages/publications/77952229661
U2 - 10.4070/kcj.2010.40.4.172
DO - 10.4070/kcj.2010.40.4.172
M3 - Article
AN - SCOPUS:77952229661
SN - 1738-5520
VL - 40
SP - 172
EP - 178
JO - Korean Circulation Journal
JF - Korean Circulation Journal
IS - 4
ER -
