The Principles and Practice of Alpha-1 Antitrypsin Clearance

Eun Ran Kim

doi:10.1007/978-981-16-7239-2_32

The Principles and Practice of Alpha-1 Antitrypsin Clearance

Eun Ran Kim

Sungkyunkwan University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Protein-losing enteropathy is defined as a diverse group of disorders associated with excessive loss of serum protein through the GI tract. Protein loss through the GI tract had been measured by the fecal excretion of labeled protein following intravenous administration of radioactive materials. However, this method has limits such as the requisite radioactive exposure and the long experimental period. α₁-antitrypsin (α₁-AT) is mainly synthesized and secreted by hepatocytes. Also, because α₁-AT inhibits various proteases, it is neither absorbed nor physiologically secreted into the intestine. Therefore, measurement of its fecal loss is indicative of the rate of loss of similar sized serum proteins. Fecal α₁-AT clearance is a more reliable marker than fecal α₁-AT concentration. α₁-AT clearance can be calculated by measuring the α₁-AT levels in both serum and a 24-hourly stool sample.

Original language	English
Title of host publication	Small Intestine Disease
Subtitle of host publication	A Comprehensive Guide to Diagnosis and Management
Publisher	Springer Nature
Pages	165-167
Number of pages	3
ISBN (Electronic)	9789811672392
ISBN (Print)	9789811672385
DOIs	https://doi.org/10.1007/978-981-16-7239-2_32
State	Published - 1 Jan 2022
Externally published	Yes

Keywords

Fecal α-AT clearance
Hypoalbuminemia
Hypoproteinemia
Protein-losing enteropathy
α-antitrypsin

Access to Document

10.1007/978-981-16-7239-2_32

Cite this

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abstract = "Protein-losing enteropathy is defined as a diverse group of disorders associated with excessive loss of serum protein through the GI tract. Protein loss through the GI tract had been measured by the fecal excretion of labeled protein following intravenous administration of radioactive materials. However, this method has limits such as the requisite radioactive exposure and the long experimental period. α1-antitrypsin (α1-AT) is mainly synthesized and secreted by hepatocytes. Also, because α1-AT inhibits various proteases, it is neither absorbed nor physiologically secreted into the intestine. Therefore, measurement of its fecal loss is indicative of the rate of loss of similar sized serum proteins. Fecal α1-AT clearance is a more reliable marker than fecal α1-AT concentration. α1-AT clearance can be calculated by measuring the α1-AT levels in both serum and a 24-hourly stool sample.",

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N2 - Protein-losing enteropathy is defined as a diverse group of disorders associated with excessive loss of serum protein through the GI tract. Protein loss through the GI tract had been measured by the fecal excretion of labeled protein following intravenous administration of radioactive materials. However, this method has limits such as the requisite radioactive exposure and the long experimental period. α1-antitrypsin (α1-AT) is mainly synthesized and secreted by hepatocytes. Also, because α1-AT inhibits various proteases, it is neither absorbed nor physiologically secreted into the intestine. Therefore, measurement of its fecal loss is indicative of the rate of loss of similar sized serum proteins. Fecal α1-AT clearance is a more reliable marker than fecal α1-AT concentration. α1-AT clearance can be calculated by measuring the α1-AT levels in both serum and a 24-hourly stool sample.

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The Principles and Practice of Alpha-1 Antitrypsin Clearance

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Keywords

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