The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer

Jung Hoon Kim; Jaewhan Song; Kye Won Park

doi:10.1007/s12272-015-0559-x

The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer

Jung Hoon Kim
, Jaewhan Song
, Kye Won Park

Department of Food Science and Biotechnology

Yonsei University

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

The consumption of high-calorie foods combined with less physical exercise has increased the prevalence of obesity. Obesity is also associated with high blood pressure, atherosclerosis, insulin resistance, diabetes, impaired host defense, and the risk of some cancers. Because PPARγ is a central player that participates in various biological responses, including lipid metabolism, inflammation, and cell proliferation, further understanding of the lipid metabolic sensor PPARγ is necessary to reduce the incidence of metabolic diseases and cancer.

Original language	English
Pages (from-to)	302-312
Number of pages	11
Journal	Archives of Pharmacal Research
Volume	38
Issue number	3
DOIs	https://doi.org/10.1007/s12272-015-0559-x
State	Published - Mar 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Immunity
Metabolism
Obesity
PPARγ

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10.1007/s12272-015-0559-x

Cite this

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title = "The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer",

abstract = "The consumption of high-calorie foods combined with less physical exercise has increased the prevalence of obesity. Obesity is also associated with high blood pressure, atherosclerosis, insulin resistance, diabetes, impaired host defense, and the risk of some cancers. Because PPARγ is a central player that participates in various biological responses, including lipid metabolism, inflammation, and cell proliferation, further understanding of the lipid metabolic sensor PPARγ is necessary to reduce the incidence of metabolic diseases and cancer.",

keywords = "Cancer, Immunity, Metabolism, Obesity, PPARγ",

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language = "English",

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AU - Kim, Jung Hoon

AU - Song, Jaewhan

AU - Park, Kye Won

PY - 2015/3

Y1 - 2015/3

N2 - The consumption of high-calorie foods combined with less physical exercise has increased the prevalence of obesity. Obesity is also associated with high blood pressure, atherosclerosis, insulin resistance, diabetes, impaired host defense, and the risk of some cancers. Because PPARγ is a central player that participates in various biological responses, including lipid metabolism, inflammation, and cell proliferation, further understanding of the lipid metabolic sensor PPARγ is necessary to reduce the incidence of metabolic diseases and cancer.

AB - The consumption of high-calorie foods combined with less physical exercise has increased the prevalence of obesity. Obesity is also associated with high blood pressure, atherosclerosis, insulin resistance, diabetes, impaired host defense, and the risk of some cancers. Because PPARγ is a central player that participates in various biological responses, including lipid metabolism, inflammation, and cell proliferation, further understanding of the lipid metabolic sensor PPARγ is necessary to reduce the incidence of metabolic diseases and cancer.

KW - Cancer

KW - Immunity

KW - Metabolism

KW - Obesity

KW - PPARγ

UR - https://www.scopus.com/pages/publications/84925481394

U2 - 10.1007/s12272-015-0559-x

DO - 10.1007/s12272-015-0559-x

M3 - Review article

C2 - 25579849

AN - SCOPUS:84925481394

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VL - 38

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JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 3

ER -

The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer

Abstract

UN SDGs

Keywords

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