The inhibitory effects of the ethanolic extract of Pimpinella brachycarpa on cytochrome P450 enzymes in humans

Heung Chan O; Jae Yun Hwang; Yoon Ae Lee; Min Song; Oh Kwang Kwon; Ju Hee Sim; Sunju Kim; Kyung Sik Song; Sangkyu Lee

doi:10.1007/s13765-013-4206-2

The inhibitory effects of the ethanolic extract of Pimpinella brachycarpa on cytochrome P450 enzymes in humans

Heung Chan O
, Jae Yun Hwang
, Yoon Ae Lee
, Min Song
, Oh Kwang Kwon
, Ju Hee Sim
, Sunju Kim
, Kyung Sik Song
, Sangkyu Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Pimpinella brachycarp is a widely distributed vegetable with known antibacterial, antitumor, antioxidant, antithrombotic, and anti-inflammatory effects. In the present study, a cocktail probe assay and LC-MS/MS were used to investigate the modulating effect of the ethanolic extract of P. brachycarp on CYP enzymes in human liver microsomes. The extract significantly inhibited CYP 1A2, 2B6, and 3A4 by mix-mode inhibition and CYP2C19 and 2D6 by competitive inhibition.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume	57
Issue number	1
DOIs	https://doi.org/10.1007/s13765-013-4206-2
State	Published - Feb 2014
Externally published	Yes

Keywords

Cytochrome P450
herb-drug interaction
human liver microsomes
Pimpinella brachycarpa

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10.1007/s13765-013-4206-2

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abstract = "Pimpinella brachycarp is a widely distributed vegetable with known antibacterial, antitumor, antioxidant, antithrombotic, and anti-inflammatory effects. In the present study, a cocktail probe assay and LC-MS/MS were used to investigate the modulating effect of the ethanolic extract of P. brachycarp on CYP enzymes in human liver microsomes. The extract significantly inhibited CYP 1A2, 2B6, and 3A4 by mix-mode inhibition and CYP2C19 and 2D6 by competitive inhibition.",

keywords = "Cytochrome P450, herb-drug interaction, human liver microsomes, Pimpinella brachycarpa",

author = "O, \{Heung Chan\} and Hwang, \{Jae Yun\} and Lee, \{Yoon Ae\} and Min Song and Kwon, \{Oh Kwang\} and Sim, \{Ju Hee\} and Sunju Kim and Song, \{Kyung Sik\} and Sangkyu Lee",

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doi = "10.1007/s13765-013-4206-2",

language = "English",

volume = "57",

pages = "113--116",

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T1 - The inhibitory effects of the ethanolic extract of Pimpinella brachycarpa on cytochrome P450 enzymes in humans

AU - O, Heung Chan

AU - Hwang, Jae Yun

AU - Lee, Yoon Ae

AU - Song, Min

AU - Kwon, Oh Kwang

AU - Sim, Ju Hee

AU - Kim, Sunju

AU - Song, Kyung Sik

AU - Lee, Sangkyu

PY - 2014/2

Y1 - 2014/2

N2 - Pimpinella brachycarp is a widely distributed vegetable with known antibacterial, antitumor, antioxidant, antithrombotic, and anti-inflammatory effects. In the present study, a cocktail probe assay and LC-MS/MS were used to investigate the modulating effect of the ethanolic extract of P. brachycarp on CYP enzymes in human liver microsomes. The extract significantly inhibited CYP 1A2, 2B6, and 3A4 by mix-mode inhibition and CYP2C19 and 2D6 by competitive inhibition.

AB - Pimpinella brachycarp is a widely distributed vegetable with known antibacterial, antitumor, antioxidant, antithrombotic, and anti-inflammatory effects. In the present study, a cocktail probe assay and LC-MS/MS were used to investigate the modulating effect of the ethanolic extract of P. brachycarp on CYP enzymes in human liver microsomes. The extract significantly inhibited CYP 1A2, 2B6, and 3A4 by mix-mode inhibition and CYP2C19 and 2D6 by competitive inhibition.

KW - Cytochrome P450

KW - herb-drug interaction

KW - human liver microsomes

KW - Pimpinella brachycarpa

UR - https://www.scopus.com/pages/publications/84897766834

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DO - 10.1007/s13765-013-4206-2

M3 - Article

AN - SCOPUS:84897766834

SN - 1738-2203

VL - 57

SP - 113

EP - 116

JO - Journal of the Korean Society for Applied Biological Chemistry

JF - Journal of the Korean Society for Applied Biological Chemistry

IS - 1

ER -

The inhibitory effects of the ethanolic extract of Pimpinella brachycarpa on cytochrome P450 enzymes in humans

Abstract

Keywords

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