The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology

Kelly A. Hirko; Gabrielle Rocque; Erica Reasor; Ammanuel Taye; Alex Daly; Ramsey I. Cutress; Ellen R. Copson; Dae Won Lee; Kyung Hun Lee; Seock Ah Im; Yeon Hee Park

doi:10.1186/s12916-022-02260-0

The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology

Kelly A. Hirko
, Gabrielle Rocque
, Erica Reasor
, Ammanuel Taye
, Alex Daly
, Ramsey I. Cutress
, Ellen R. Copson
, Dae Won Lee
, Kyung Hun Lee
, Seock Ah Im
, Yeon Hee Park

Michigan State University
University of Alabama at Birmingham
University of Southampton
Seoul National University
Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. The incidence, pathological features, and clinical outcomes in breast cancer differ by geographical distribution and across racial and ethnic populations. Importantly, racial and ethnic diversity in breast cancer clinical trials is lacking, with both Blacks and Hispanics underrepresented. In this forum article, breast cancer researchers from across the globe discuss the factors contributing to racial and ethnic breast cancer disparities and highlight specific implications of precision oncology approaches for equitable provision of breast cancer care to improve outcomes and address disparities.

Original language	English
Article number	72
Journal	BMC Medicine
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12916-022-02260-0
State	Published - Dec 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BRCA mutations
Breast cancer
CDK4/6 inhibitors
Clinical outcomes
Disparities
Ethnicity
PARP inhibitors
Precision oncology
Race
Socioeconomic status
Targeted therapy

Access to Document

10.1186/s12916-022-02260-0

Cite this

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title = "The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology",

abstract = "Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. The incidence, pathological features, and clinical outcomes in breast cancer differ by geographical distribution and across racial and ethnic populations. Importantly, racial and ethnic diversity in breast cancer clinical trials is lacking, with both Blacks and Hispanics underrepresented. In this forum article, breast cancer researchers from across the globe discuss the factors contributing to racial and ethnic breast cancer disparities and highlight specific implications of precision oncology approaches for equitable provision of breast cancer care to improve outcomes and address disparities.",

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doi = "10.1186/s12916-022-02260-0",

language = "English",

volume = "20",

journal = "BMC Medicine",

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T1 - The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology

AU - Hirko, Kelly A.

AU - Rocque, Gabrielle

AU - Reasor, Erica

AU - Taye, Ammanuel

AU - Daly, Alex

AU - Cutress, Ramsey I.

AU - Copson, Ellen R.

AU - Lee, Dae Won

AU - Lee, Kyung Hun

AU - Im, Seock Ah

AU - Park, Yeon Hee

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N2 - Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. The incidence, pathological features, and clinical outcomes in breast cancer differ by geographical distribution and across racial and ethnic populations. Importantly, racial and ethnic diversity in breast cancer clinical trials is lacking, with both Blacks and Hispanics underrepresented. In this forum article, breast cancer researchers from across the globe discuss the factors contributing to racial and ethnic breast cancer disparities and highlight specific implications of precision oncology approaches for equitable provision of breast cancer care to improve outcomes and address disparities.

AB - Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. The incidence, pathological features, and clinical outcomes in breast cancer differ by geographical distribution and across racial and ethnic populations. Importantly, racial and ethnic diversity in breast cancer clinical trials is lacking, with both Blacks and Hispanics underrepresented. In this forum article, breast cancer researchers from across the globe discuss the factors contributing to racial and ethnic breast cancer disparities and highlight specific implications of precision oncology approaches for equitable provision of breast cancer care to improve outcomes and address disparities.

KW - BRCA mutations

KW - Breast cancer

KW - CDK4/6 inhibitors

KW - Clinical outcomes

KW - Disparities

KW - Ethnicity

KW - PARP inhibitors

KW - Precision oncology

KW - Race

KW - Socioeconomic status

KW - Targeted therapy

UR - https://www.scopus.com/pages/publications/85124590613

U2 - 10.1186/s12916-022-02260-0

DO - 10.1186/s12916-022-02260-0

M3 - Article

C2 - 35151316

AN - SCOPUS:85124590613

SN - 1741-7015

VL - 20

JO - BMC Medicine

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ER -

The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology

Abstract

UN SDGs

Keywords

Access to Document

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