The effects of PVA/Chitosan/Fibroin (PCF)-blended spongy sheets on wound healing in rats

Joo Hong Yeo; Kwang Gill Lee; Ho Cheol Kim; Young Lyun Oh; Ae Jeong Kim; Sun Yeou Kim

doi:10.1248/bpb.23.1220

The effects of PVA/Chitosan/Fibroin (PCF)-blended spongy sheets on wound healing in rats

Joo Hong Yeo, Kwang Gill Lee, Ho Cheol Kim, Young Lyun Oh, Ae Jeong Kim, Sun Yeou Kim

Department of Pathology and Translational Genomics

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

The effects of poly vinyl alcohol (PVA)/Chitosan/Fibroin (PCF)-blended sponge on wound healing in rats were investigated. We excised the skin of a rat, including the dermis, approximately 2x2 cm in size. The wound was covered with PCF-blended spongy sheets. The spongy sheets absorbed the exudate, and gained flexibility and softness. Histopathological inspection of the wound 12d later showed an increase of vascular ingrowth and the absence of inflammatory cells. Regeneration of the skin around the wound was faster than that of the control. We also tested wound healing effects of PVA, Chitosan and Fibroin, alone or in various combinations. Wound healing was accelerated in the order of PCF-blended sponge>Chitosan/Fibroin (CF)-blended sponge≥Fibroin (F) sponge>PVA/Chitosan-blended sponge (PC)>Chitosan (C) sponge.

Original language	English
Pages (from-to)	1220-1223
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	23
Issue number	10
DOIs	https://doi.org/10.1248/bpb.23.1220
State	Published - 2000

Keywords

Histopathological inspection
PVA/Chitosan/Fibroin (PCF)-blended sponge
Wound healing

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title = "The effects of PVA/Chitosan/Fibroin (PCF)-blended spongy sheets on wound healing in rats",

abstract = "The effects of poly vinyl alcohol (PVA)/Chitosan/Fibroin (PCF)-blended sponge on wound healing in rats were investigated. We excised the skin of a rat, including the dermis, approximately 2x2 cm in size. The wound was covered with PCF-blended spongy sheets. The spongy sheets absorbed the exudate, and gained flexibility and softness. Histopathological inspection of the wound 12d later showed an increase of vascular ingrowth and the absence of inflammatory cells. Regeneration of the skin around the wound was faster than that of the control. We also tested wound healing effects of PVA, Chitosan and Fibroin, alone or in various combinations. Wound healing was accelerated in the order of PCF-blended sponge>Chitosan/Fibroin (CF)-blended sponge≥Fibroin (F) sponge>PVA/Chitosan-blended sponge (PC)>Chitosan (C) sponge.",

keywords = "Histopathological inspection, PVA/Chitosan/Fibroin (PCF)-blended sponge, Wound healing",

author = "Yeo, \{Joo Hong\} and Lee, \{Kwang Gill\} and Kim, \{Ho Cheol\} and Oh, \{Young Lyun\} and Kim, \{Ae Jeong\} and Kim, \{Sun Yeou\}",

year = "2000",

doi = "10.1248/bpb.23.1220",

language = "English",

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journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

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T1 - The effects of PVA/Chitosan/Fibroin (PCF)-blended spongy sheets on wound healing in rats

AU - Yeo, Joo Hong

AU - Lee, Kwang Gill

AU - Kim, Ho Cheol

AU - Oh, Young Lyun

AU - Kim, Ae Jeong

AU - Kim, Sun Yeou

PY - 2000

Y1 - 2000

N2 - The effects of poly vinyl alcohol (PVA)/Chitosan/Fibroin (PCF)-blended sponge on wound healing in rats were investigated. We excised the skin of a rat, including the dermis, approximately 2x2 cm in size. The wound was covered with PCF-blended spongy sheets. The spongy sheets absorbed the exudate, and gained flexibility and softness. Histopathological inspection of the wound 12d later showed an increase of vascular ingrowth and the absence of inflammatory cells. Regeneration of the skin around the wound was faster than that of the control. We also tested wound healing effects of PVA, Chitosan and Fibroin, alone or in various combinations. Wound healing was accelerated in the order of PCF-blended sponge>Chitosan/Fibroin (CF)-blended sponge≥Fibroin (F) sponge>PVA/Chitosan-blended sponge (PC)>Chitosan (C) sponge.

AB - The effects of poly vinyl alcohol (PVA)/Chitosan/Fibroin (PCF)-blended sponge on wound healing in rats were investigated. We excised the skin of a rat, including the dermis, approximately 2x2 cm in size. The wound was covered with PCF-blended spongy sheets. The spongy sheets absorbed the exudate, and gained flexibility and softness. Histopathological inspection of the wound 12d later showed an increase of vascular ingrowth and the absence of inflammatory cells. Regeneration of the skin around the wound was faster than that of the control. We also tested wound healing effects of PVA, Chitosan and Fibroin, alone or in various combinations. Wound healing was accelerated in the order of PCF-blended sponge>Chitosan/Fibroin (CF)-blended sponge≥Fibroin (F) sponge>PVA/Chitosan-blended sponge (PC)>Chitosan (C) sponge.

KW - Histopathological inspection

KW - PVA/Chitosan/Fibroin (PCF)-blended sponge

KW - Wound healing

UR - https://www.scopus.com/pages/publications/0033787270

U2 - 10.1248/bpb.23.1220

DO - 10.1248/bpb.23.1220

M3 - Article

AN - SCOPUS:0033787270

SN - 0918-6158

VL - 23

SP - 1220

EP - 1223

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 10

ER -

The effects of PVA/Chitosan/Fibroin (PCF)-blended spongy sheets on wound healing in rats

Abstract

Keywords

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