Targeted theranostic nanoparticles: Receptor-mediated entry into cells, pH-induced signal generation and cytosolic delivery

Ji Yeon Lee; Doo Yeol Choi; Mi Young Cho; Kyoung Eun Park; Seon Ho Lee; Seong Hun Cho; Kwan Soo Hong; Yong Taik Lim

doi:10.1002/smll.201302136

Targeted theranostic nanoparticles: Receptor-mediated entry into cells, pH-induced signal generation and cytosolic delivery

Ji Yeon Lee, Doo Yeol Choi, Mi Young Cho, Kyoung Eun Park, Seon Ho Lee, Seong Hun Cho, Kwan Soo Hong, Yong Taik Lim

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Virus-like theranostic nanoparticles: virus-like poly(amino acid) nanoparticles are synthesized that can be internalized via receptor-mediated endocytosis, resulting in encapsulated pH-activatable fluorescence probes that can be turned on in acidic environments but otherwise remain undetectable. The encapsulated anticancer drugs are also released into cytosol by endosome disruption.

Original language	English
Pages (from-to)	901-906
Number of pages	6
Journal	Small
Volume	10
Issue number	5
DOIs	https://doi.org/10.1002/smll.201302136
State	Published - 12 Mar 2014
Externally published	Yes

Keywords

cancer cells
fluorescence
hydrophobicity
polymeric nanoparticles
theranosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/smll.201302136

Cite this

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title = "Targeted theranostic nanoparticles: Receptor-mediated entry into cells, pH-induced signal generation and cytosolic delivery",

abstract = "Virus-like theranostic nanoparticles: virus-like poly(amino acid) nanoparticles are synthesized that can be internalized via receptor-mediated endocytosis, resulting in encapsulated pH-activatable fluorescence probes that can be turned on in acidic environments but otherwise remain undetectable. The encapsulated anticancer drugs are also released into cytosol by endosome disruption.",

keywords = "cancer cells, fluorescence, hydrophobicity, polymeric nanoparticles, theranosis",

author = "Lee, \{Ji Yeon\} and Choi, \{Doo Yeol\} and Cho, \{Mi Young\} and Park, \{Kyoung Eun\} and Lee, \{Seon Ho\} and \{Hun Cho\}, Seong and Hong, \{Kwan Soo\} and Lim, \{Yong Taik\}",

year = "2014",

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doi = "10.1002/smll.201302136",

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T2 - Receptor-mediated entry into cells, pH-induced signal generation and cytosolic delivery

AU - Lee, Ji Yeon

AU - Choi, Doo Yeol

AU - Cho, Mi Young

AU - Park, Kyoung Eun

AU - Lee, Seon Ho

AU - Hun Cho, Seong

AU - Hong, Kwan Soo

AU - Lim, Yong Taik

PY - 2014/3/12

Y1 - 2014/3/12

N2 - Virus-like theranostic nanoparticles: virus-like poly(amino acid) nanoparticles are synthesized that can be internalized via receptor-mediated endocytosis, resulting in encapsulated pH-activatable fluorescence probes that can be turned on in acidic environments but otherwise remain undetectable. The encapsulated anticancer drugs are also released into cytosol by endosome disruption.

AB - Virus-like theranostic nanoparticles: virus-like poly(amino acid) nanoparticles are synthesized that can be internalized via receptor-mediated endocytosis, resulting in encapsulated pH-activatable fluorescence probes that can be turned on in acidic environments but otherwise remain undetectable. The encapsulated anticancer drugs are also released into cytosol by endosome disruption.

KW - cancer cells

KW - fluorescence

KW - hydrophobicity

KW - polymeric nanoparticles

KW - theranosis

UR - https://www.scopus.com/pages/publications/84896708922

U2 - 10.1002/smll.201302136

DO - 10.1002/smll.201302136

M3 - Article

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JO - Small

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ER -

Targeted theranostic nanoparticles: Receptor-mediated entry into cells, pH-induced signal generation and cytosolic delivery

Abstract

Keywords

UN SDGs

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