Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets

Tung Thanh Pham; Hanh Thuy Nguyen; Cao Dai Phung; Shiva Pathak; Shobha Regmi; Dong Ho Ha; Jong Oh Kim; Chul Soon Yong; Sang Kyoon Kim; Ji Eun Choi; Simmyung Yook; Jun Beom Park; Jee Heon Jeong

doi:10.1016/j.jiec.2019.03.055

Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets

Tung Thanh Pham
, Hanh Thuy Nguyen
, Cao Dai Phung
, Shiva Pathak
, Shobha Regmi
, Dong Ho Ha
, Jong Oh Kim
, Chul Soon Yong
, Sang Kyoon Kim
, Ji Eun Choi
, Simmyung Yook
, Jun Beom Park
, Jee Heon Jeong

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Selective delivery of anti-cancer drugs to bone tumors remains an on-going developmental issue due to problems of drug availability and the physiological nature of bone. This study was undertaken to enhance accumulation of doxorubicin (DOX) in bone metastasis microenvironments using alendronate-functionalized graphene oxide nanosheets (NGO-ALs). In vivo biodistribution study showed NGO-ALs were retained for longer and at higher concentrations in bone tumor areas than non-functionalized NGOs. Our findings suggest that NGO-ALs could be used as a promising carrier to enhance antitumor effects and diminish the off-target effects of DOX for the treatment of bone metastasis.

Original language	English
Pages (from-to)	310-317
Number of pages	8
Journal	Journal of Industrial and Engineering Chemistry
Volume	76
DOIs	https://doi.org/10.1016/j.jiec.2019.03.055
State	Published - 25 Aug 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alendronate
Bone metastasis
Graphene oxides
Targeted delivery

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10.1016/j.jiec.2019.03.055

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Pham, T. T., Nguyen, H. T., Phung, C. D., Pathak, S., Regmi, S., Ha, D. H., Kim, J. O., Yong, C. S., Kim, S. K., Choi, J. E., Yook, S., Park, J. B., & Jeong, J. H. (2019). Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets. Journal of Industrial and Engineering Chemistry, 76, 310-317. https://doi.org/10.1016/j.jiec.2019.03.055

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title = "Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets",

abstract = "Selective delivery of anti-cancer drugs to bone tumors remains an on-going developmental issue due to problems of drug availability and the physiological nature of bone. This study was undertaken to enhance accumulation of doxorubicin (DOX) in bone metastasis microenvironments using alendronate-functionalized graphene oxide nanosheets (NGO-ALs). In vivo biodistribution study showed NGO-ALs were retained for longer and at higher concentrations in bone tumor areas than non-functionalized NGOs. Our findings suggest that NGO-ALs could be used as a promising carrier to enhance antitumor effects and diminish the off-target effects of DOX for the treatment of bone metastasis.",

keywords = "Alendronate, Bone metastasis, Graphene oxides, Targeted delivery",

author = "Pham, \{Tung Thanh\} and Nguyen, \{Hanh Thuy\} and Phung, \{Cao Dai\} and Shiva Pathak and Shobha Regmi and Ha, \{Dong Ho\} and Kim, \{Jong Oh\} and Yong, \{Chul Soon\} and Kim, \{Sang Kyoon\} and Choi, \{Ji Eun\} and Simmyung Yook and Park, \{Jun Beom\} and Jeong, \{Jee Heon\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Korean Society of Industrial and Engineering Chemistry",

year = "2019",

month = aug,

day = "25",

doi = "10.1016/j.jiec.2019.03.055",

language = "English",

volume = "76",

pages = "310--317",

journal = "Journal of Industrial and Engineering Chemistry",

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publisher = "Korean Society of Industrial Engineering Chemistry",

}

Pham, TT, Nguyen, HT, Phung, CD, Pathak, S, Regmi, S, Ha, DH, Kim, JO, Yong, CS, Kim, SK, Choi, JE, Yook, S, Park, JB & Jeong, JH 2019, 'Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets', Journal of Industrial and Engineering Chemistry, vol. 76, pp. 310-317. https://doi.org/10.1016/j.jiec.2019.03.055

TY - JOUR

T1 - Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets

AU - Pham, Tung Thanh

AU - Nguyen, Hanh Thuy

AU - Phung, Cao Dai

AU - Pathak, Shiva

AU - Regmi, Shobha

AU - Ha, Dong Ho

AU - Kim, Jong Oh

AU - Yong, Chul Soon

AU - Kim, Sang Kyoon

AU - Choi, Ji Eun

AU - Yook, Simmyung

AU - Park, Jun Beom

AU - Jeong, Jee Heon

PY - 2019/8/25

Y1 - 2019/8/25

N2 - Selective delivery of anti-cancer drugs to bone tumors remains an on-going developmental issue due to problems of drug availability and the physiological nature of bone. This study was undertaken to enhance accumulation of doxorubicin (DOX) in bone metastasis microenvironments using alendronate-functionalized graphene oxide nanosheets (NGO-ALs). In vivo biodistribution study showed NGO-ALs were retained for longer and at higher concentrations in bone tumor areas than non-functionalized NGOs. Our findings suggest that NGO-ALs could be used as a promising carrier to enhance antitumor effects and diminish the off-target effects of DOX for the treatment of bone metastasis.

AB - Selective delivery of anti-cancer drugs to bone tumors remains an on-going developmental issue due to problems of drug availability and the physiological nature of bone. This study was undertaken to enhance accumulation of doxorubicin (DOX) in bone metastasis microenvironments using alendronate-functionalized graphene oxide nanosheets (NGO-ALs). In vivo biodistribution study showed NGO-ALs were retained for longer and at higher concentrations in bone tumor areas than non-functionalized NGOs. Our findings suggest that NGO-ALs could be used as a promising carrier to enhance antitumor effects and diminish the off-target effects of DOX for the treatment of bone metastasis.

KW - Alendronate

KW - Bone metastasis

KW - Graphene oxides

KW - Targeted delivery

UR - https://www.scopus.com/pages/publications/85064455287

U2 - 10.1016/j.jiec.2019.03.055

DO - 10.1016/j.jiec.2019.03.055

M3 - Article

AN - SCOPUS:85064455287

SN - 1226-086X

VL - 76

SP - 310

EP - 317

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets

Abstract

UN SDGs

Keywords

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