Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

Eonjeong Park; Yoon Jung Yang; Aejin Kim; Jong Hwan Kwak; Young Hoon Jung; Se Chan Kang; In Su Kim

doi:10.1016/j.bmcl.2012.04.033

Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

Eonjeong Park
, Yoon Jung Yang
, Aejin Kim
, Jong Hwan Kwak
, Young Hoon Jung
, Se Chan Kang
, In Su Kim

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC₅₀ values of 18.3 and 17.9 μM, respectively.

Original language	English
Pages (from-to)	3653-3655
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2012.04.033
State	Published - 1 Jun 2012
Externally published	Yes

Keywords

Allergy
Degranulation
Derivative
IgE
Norlignan

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2012.04.033

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title = "Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation",

abstract = "The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC50 values of 18.3 and 17.9 μM, respectively.",

keywords = "Allergy, Degranulation, Derivative, IgE, Norlignan",

author = "Eonjeong Park and Yang, \{Yoon Jung\} and Aejin Kim and Kwak, \{Jong Hwan\} and Jung, \{Young Hoon\} and Kang, \{Se Chan\} and Kim, \{In Su\}",

year = "2012",

month = jun,

day = "1",

doi = "10.1016/j.bmcl.2012.04.033",

language = "English",

volume = "22",

pages = "3653--3655",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "11",

}

TY - JOUR

T1 - Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

AU - Park, Eonjeong

AU - Yang, Yoon Jung

AU - Kim, Aejin

AU - Kwak, Jong Hwan

AU - Jung, Young Hoon

AU - Kang, Se Chan

AU - Kim, In Su

PY - 2012/6/1

Y1 - 2012/6/1

N2 - The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC50 values of 18.3 and 17.9 μM, respectively.

AB - The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC50 values of 18.3 and 17.9 μM, respectively.

KW - Allergy

KW - Degranulation

KW - Derivative

KW - IgE

KW - Norlignan

UR - https://www.scopus.com/pages/publications/84861193892

U2 - 10.1016/j.bmcl.2012.04.033

DO - 10.1016/j.bmcl.2012.04.033

M3 - Article

C2 - 22543029

AN - SCOPUS:84861193892

SN - 0960-894X

VL - 22

SP - 3653

EP - 3655

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

Abstract

Keywords

UN SDGs

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