Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase

Iljung Lee; Yearn Seong Choe; Eun Kyoung Ryu; Byoung Wook Choi; Joon Young Choi; Yong Choi; Kyung Han Lee; Byung Tae Kim

doi:10.1097/MNM.0b013e328194f1f7

Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase

Iljung Lee
, Yearn Seong Choe
, Eun Kyoung Ryu
, Byoung Wook Choi
, Joon Young Choi
, Yong Choi
, Kyung Han Lee
, Byung Tae Kim

Sungkyunkwan University
Hanbat National University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Alzheimer's disease (AD) is characterized by reduced acetylcholinesterase (AChE) activity in the post-mortem tissues of AD patients. Therefore, AChE has been an attractive target for the diagnosis of AD. In the present study, 5,7-dihydro-3-[2-(1-(phenylmethyl)-4-piperidinyl)ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one (CP-118,954), a potent AChE inhibitor, was labelled with radioiodine and evaluated as an AChE imaging agent for SPECT.

Original language	English
Pages (from-to)	561-566
Number of pages	6
Journal	Nuclear Medicine Communications
Volume	28
Issue number	7
DOIs	https://doi.org/10.1097/MNM.0b013e328194f1f7
State	Published - Jul 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

954
Acetylcholinesterase
Alzheimer's disease

Access to Document

10.1097/MNM.0b013e328194f1f7

Cite this

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title = "Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase",

abstract = "Alzheimer's disease (AD) is characterized by reduced acetylcholinesterase (AChE) activity in the post-mortem tissues of AD patients. Therefore, AChE has been an attractive target for the diagnosis of AD. In the present study, 5,7-dihydro-3-[2-(1-(phenylmethyl)-4-piperidinyl)ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one (CP-118,954), a potent AChE inhibitor, was labelled with radioiodine and evaluated as an AChE imaging agent for SPECT.",

keywords = "954, Acetylcholinesterase, Alzheimer's disease",

author = "Iljung Lee and Choe, \{Yearn Seong\} and Ryu, \{Eun Kyoung\} and Choi, \{Byoung Wook\} and Choi, \{Joon Young\} and Yong Choi and Lee, \{Kyung Han\} and Kim, \{Byung Tae\}",

year = "2007",

month = jul,

doi = "10.1097/MNM.0b013e328194f1f7",

language = "English",

volume = "28",

pages = "561--566",

journal = "Nuclear Medicine Communications",

issn = "0143-3636",

publisher = "Wolters Kluwer Health",

number = "7",

}

TY - JOUR

T1 - Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase

AU - Lee, Iljung

AU - Choe, Yearn Seong

AU - Ryu, Eun Kyoung

AU - Choi, Byoung Wook

AU - Choi, Joon Young

AU - Choi, Yong

AU - Lee, Kyung Han

AU - Kim, Byung Tae

PY - 2007/7

Y1 - 2007/7

N2 - Alzheimer's disease (AD) is characterized by reduced acetylcholinesterase (AChE) activity in the post-mortem tissues of AD patients. Therefore, AChE has been an attractive target for the diagnosis of AD. In the present study, 5,7-dihydro-3-[2-(1-(phenylmethyl)-4-piperidinyl)ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one (CP-118,954), a potent AChE inhibitor, was labelled with radioiodine and evaluated as an AChE imaging agent for SPECT.

AB - Alzheimer's disease (AD) is characterized by reduced acetylcholinesterase (AChE) activity in the post-mortem tissues of AD patients. Therefore, AChE has been an attractive target for the diagnosis of AD. In the present study, 5,7-dihydro-3-[2-(1-(phenylmethyl)-4-piperidinyl)ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one (CP-118,954), a potent AChE inhibitor, was labelled with radioiodine and evaluated as an AChE imaging agent for SPECT.

KW - 954

KW - Acetylcholinesterase

KW - Alzheimer's disease

UR - https://www.scopus.com/pages/publications/34249795770

U2 - 10.1097/MNM.0b013e328194f1f7

DO - 10.1097/MNM.0b013e328194f1f7

M3 - Article

C2 - 17538398

AN - SCOPUS:34249795770

SN - 0143-3636

VL - 28

SP - 561

EP - 566

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

IS - 7

ER -

Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase

Abstract

UN SDGs

Keywords

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