Synthesis and Cell Death Mechanism of a Militarin Derivative

Fei Chen; Deok Hyo Yoon; Dinneswara Reddy; Changwoo Han; Sunga Choi; Jae Youl Cho; Gi Ho Sung; Ki Chul Hwang; Tae Woong Kim; Haeil Park

doi:10.1002/bkcs.10667

Synthesis and Cell Death Mechanism of a Militarin Derivative

Fei Chen
, Deok Hyo Yoon
, Dinneswara Reddy
, Changwoo Han
, Sunga Choi
, Jae Youl Cho
, Gi Ho Sung
, Ki Chul Hwang
, Tae Woong Kim
, Haeil Park

Department of Integrative Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Militarin, a novel anticancer substance from a caterpillar-grown traditional insect-flower (Cordyceps militaris), was previously isolated and characterized as an ether compound of 4-tert-octylphenol and a nonaethylene glycol. Among militarin analogs with different numbers of ethylene glycol substructure, the analog with four ethylene glycol substructure (M4EG) exhibited potent anticancer activities. A facile and scalable synthetic pathway of the M4EG was developed and the mechanism of cell death by the M4EG against lung adenocarcinoma epithelial cell line (A549) was explored. The results of this study showed that apoptosis of M4EG toward A549 cells is mediated by a caspase-dependent death-signaling pathway.

Original language	English
Pages (from-to)	287-293
Number of pages	7
Journal	Bulletin of the Korean Chemical Society
Volume	37
Issue number	3
DOIs	https://doi.org/10.1002/bkcs.10667
State	Published - 1 Mar 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cell death mechanism
Cordyceps militaris
Militarin derivative
Polyethylene glycol substructure

Access to Document

10.1002/bkcs.10667

Cite this

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title = "Synthesis and Cell Death Mechanism of a Militarin Derivative",

abstract = "Militarin, a novel anticancer substance from a caterpillar-grown traditional insect-flower (Cordyceps militaris), was previously isolated and characterized as an ether compound of 4-tert-octylphenol and a nonaethylene glycol. Among militarin analogs with different numbers of ethylene glycol substructure, the analog with four ethylene glycol substructure (M4EG) exhibited potent anticancer activities. A facile and scalable synthetic pathway of the M4EG was developed and the mechanism of cell death by the M4EG against lung adenocarcinoma epithelial cell line (A549) was explored. The results of this study showed that apoptosis of M4EG toward A549 cells is mediated by a caspase-dependent death-signaling pathway.",

keywords = "Cell death mechanism, Cordyceps militaris, Militarin derivative, Polyethylene glycol substructure",

author = "Fei Chen and Yoon, \{Deok Hyo\} and Dinneswara Reddy and Changwoo Han and Sunga Choi and Cho, \{Jae Youl\} and Sung, \{Gi Ho\} and Hwang, \{Ki Chul\} and Kim, \{Tae Woong\} and Haeil Park",

note = "Publisher Copyright: {\textcopyright} 2016 Korean Chemical Society, Seoul \& Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2016",

month = mar,

day = "1",

doi = "10.1002/bkcs.10667",

language = "English",

volume = "37",

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journal = "Bulletin of the Korean Chemical Society",

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TY - JOUR

T1 - Synthesis and Cell Death Mechanism of a Militarin Derivative

AU - Chen, Fei

AU - Yoon, Deok Hyo

AU - Reddy, Dinneswara

AU - Han, Changwoo

AU - Choi, Sunga

AU - Cho, Jae Youl

AU - Sung, Gi Ho

AU - Hwang, Ki Chul

AU - Kim, Tae Woong

AU - Park, Haeil

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Militarin, a novel anticancer substance from a caterpillar-grown traditional insect-flower (Cordyceps militaris), was previously isolated and characterized as an ether compound of 4-tert-octylphenol and a nonaethylene glycol. Among militarin analogs with different numbers of ethylene glycol substructure, the analog with four ethylene glycol substructure (M4EG) exhibited potent anticancer activities. A facile and scalable synthetic pathway of the M4EG was developed and the mechanism of cell death by the M4EG against lung adenocarcinoma epithelial cell line (A549) was explored. The results of this study showed that apoptosis of M4EG toward A549 cells is mediated by a caspase-dependent death-signaling pathway.

AB - Militarin, a novel anticancer substance from a caterpillar-grown traditional insect-flower (Cordyceps militaris), was previously isolated and characterized as an ether compound of 4-tert-octylphenol and a nonaethylene glycol. Among militarin analogs with different numbers of ethylene glycol substructure, the analog with four ethylene glycol substructure (M4EG) exhibited potent anticancer activities. A facile and scalable synthetic pathway of the M4EG was developed and the mechanism of cell death by the M4EG against lung adenocarcinoma epithelial cell line (A549) was explored. The results of this study showed that apoptosis of M4EG toward A549 cells is mediated by a caspase-dependent death-signaling pathway.

KW - Cell death mechanism

KW - Cordyceps militaris

KW - Militarin derivative

KW - Polyethylene glycol substructure

UR - https://www.scopus.com/pages/publications/84960099879

U2 - 10.1002/bkcs.10667

DO - 10.1002/bkcs.10667

M3 - Article

AN - SCOPUS:84960099879

SN - 0253-2964

VL - 37

SP - 287

EP - 293

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

IS - 3

ER -

Synthesis and Cell Death Mechanism of a Militarin Derivative

Abstract

UN SDGs

Keywords

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