Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells

Dahae Lee; Ki Hyun Kim; Sung Won Moon; Heesu Lee; Ki Sung Kang; Jae Wook Lee

doi:10.1016/j.bmcl.2015.03.026

Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells

Dahae Lee
, Ki Hyun Kim
, Sung Won Moon
, Heesu Lee
, Ki Sung Kang
, Jae Wook Lee

Department of Pharmacy

Gachon University
Gyeongsang National University
Korea Institute of Science and Technology
Gangneung-Wonju National University
University of Science and Technology UST

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.

Original language	English
Pages (from-to)	1929-1932
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2015.03.026
State	Published - 1 May 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chalcone
Cisplatin-induced nephrotoxicity
MAPKs-p53-caspase-3
Renoprotection

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10.1016/j.bmcl.2015.03.026

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title = "Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells",

abstract = "Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.",

keywords = "Chalcone, Cisplatin-induced nephrotoxicity, MAPKs-p53-caspase-3, Renoprotection",

author = "Dahae Lee and Kim, \{Ki Hyun\} and Moon, \{Sung Won\} and Heesu Lee and Kang, \{Ki Sung\} and Lee, \{Jae Wook\}",

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doi = "10.1016/j.bmcl.2015.03.026",

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AU - Lee, Dahae

AU - Kim, Ki Hyun

AU - Moon, Sung Won

AU - Lee, Heesu

AU - Kang, Ki Sung

AU - Lee, Jae Wook

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.

AB - Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.

KW - Chalcone

KW - Cisplatin-induced nephrotoxicity

KW - MAPKs-p53-caspase-3

KW - Renoprotection

UR - https://www.scopus.com/pages/publications/84933497715

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DO - 10.1016/j.bmcl.2015.03.026

M3 - Article

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AN - SCOPUS:84933497715

SN - 0960-894X

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EP - 1932

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells

Abstract

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Keywords

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