Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

Kyeong Lee; Jung S. Ryu; Yinglan Jin; Woncheol Kim; Navneet Kaur; Sang J. Chung; Yong Jin Jeon; Joon Tae Park; Ji S. Bang; Hong S. Lee; Tae Y. Kim; Jung J. Lee; Young Soo Hong

doi:10.1039/b713407j

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

Kyeong Lee
, Jung S. Ryu
, Yinglan Jin
, Woncheol Kim
, Navneet Kaur
, Sang J. Chung
, Yong Jin Jeon
, Joon Tae Park
, Ji S. Bang
, Hong S. Lee
, Tae Y. Kim
, Jung J. Lee
, Young Soo Hong

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.

Original language	English
Pages (from-to)	340-348
Number of pages	9
Journal	Organic and Biomolecular Chemistry
Volume	6
Issue number	2
DOIs	https://doi.org/10.1039/b713407j
State	Published - 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1039/b713407j

Cite this

@article{36874e916179426bbf9a78c373b0a850,

title = "Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites",

abstract = "A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.",

author = "Kyeong Lee and Ryu, \{Jung S.\} and Yinglan Jin and Woncheol Kim and Navneet Kaur and Chung, \{Sang J.\} and Jeon, \{Yong Jin\} and Park, \{Joon Tae\} and Bang, \{Ji S.\} and Lee, \{Hong S.\} and Kim, \{Tae Y.\} and Lee, \{Jung J.\} and Hong, \{Young Soo\}",

year = "2008",

doi = "10.1039/b713407j",

language = "English",

volume = "6",

pages = "340--348",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "2",

}

TY - JOUR

T1 - Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

AU - Lee, Kyeong

AU - Ryu, Jung S.

AU - Jin, Yinglan

AU - Kim, Woncheol

AU - Kaur, Navneet

AU - Chung, Sang J.

AU - Jeon, Yong Jin

AU - Park, Joon Tae

AU - Bang, Ji S.

AU - Lee, Hong S.

AU - Kim, Tae Y.

AU - Lee, Jung J.

AU - Hong, Young Soo

PY - 2008

Y1 - 2008

N2 - A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.

AB - A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.

UR - https://www.scopus.com/pages/publications/37849038378

U2 - 10.1039/b713407j

DO - 10.1039/b713407j

M3 - Article

C2 - 18175003

AN - SCOPUS:37849038378

SN - 1477-0520

VL - 6

SP - 340

EP - 348

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 2

ER -

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this