Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers

Raj Kumar Thapa; Hanh Thuy Nguyen; Jee Heon Jeong; Beom Soo Shin; Sae Kwang Ku; Han Gon Choi; Chul Soon Yong; Jong Oh Kim

doi:10.1016/j.nano.2016.12.010

Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers

Raj Kumar Thapa, Hanh Thuy Nguyen, Jee Heon Jeong, Beom Soo Shin, Sae Kwang Ku, Han Gon Choi, Chul Soon Yong, Jong Oh Kim

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. We aimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (~160 nm) and polydispersity index (~0.20). Importantly, controlled and pH-dependent drug release profiles were observed. ZNP/VB exhibited high uptake in different prostate cancer cells and, thereby, exhibited higher cytotoxicity and apoptosis. Additionally, the enhanced anti-migration effect of and induction of pro-apoptotic proteins by ZNP/VB suggest its potential effectiveness in cancer treatment. ZNP/VB showed enhanced in vivo antitumor effects compared to that observed for each free drug and their combination, with minimal toxicity. Taken together, ZNP/VB could be a potential formulation for the effective treatment of metastatic prostate cancers.

Original language	English
Pages (from-to)	885-896
Number of pages	12
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.nano.2016.12.010
State	Published - 1 Apr 2017
Externally published	Yes

Keywords

Bortezomib
Prostate cancer
Vorinostat
Zein nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nano.2016.12.010

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Thapa, R. K., Nguyen, H. T., Jeong, J. H., Shin, B. S., Ku, S. K., Choi, H. G., Yong, C. S., & Kim, J. O. (2017). Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(3), 885-896. https://doi.org/10.1016/j.nano.2016.12.010

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abstract = "The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. We aimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (\textasciitilde{}160 nm) and polydispersity index (\textasciitilde{}0.20). Importantly, controlled and pH-dependent drug release profiles were observed. ZNP/VB exhibited high uptake in different prostate cancer cells and, thereby, exhibited higher cytotoxicity and apoptosis. Additionally, the enhanced anti-migration effect of and induction of pro-apoptotic proteins by ZNP/VB suggest its potential effectiveness in cancer treatment. ZNP/VB showed enhanced in vivo antitumor effects compared to that observed for each free drug and their combination, with minimal toxicity. Taken together, ZNP/VB could be a potential formulation for the effective treatment of metastatic prostate cancers.",

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Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers. / Thapa, Raj Kumar; Nguyen, Hanh Thuy; Jeong, Jee Heon et al.
In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 13, No. 3, 01.04.2017, p. 885-896.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers

AU - Thapa, Raj Kumar

AU - Nguyen, Hanh Thuy

AU - Jeong, Jee Heon

AU - Shin, Beom Soo

AU - Ku, Sae Kwang

AU - Choi, Han Gon

AU - Yong, Chul Soon

AU - Kim, Jong Oh

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. We aimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (~160 nm) and polydispersity index (~0.20). Importantly, controlled and pH-dependent drug release profiles were observed. ZNP/VB exhibited high uptake in different prostate cancer cells and, thereby, exhibited higher cytotoxicity and apoptosis. Additionally, the enhanced anti-migration effect of and induction of pro-apoptotic proteins by ZNP/VB suggest its potential effectiveness in cancer treatment. ZNP/VB showed enhanced in vivo antitumor effects compared to that observed for each free drug and their combination, with minimal toxicity. Taken together, ZNP/VB could be a potential formulation for the effective treatment of metastatic prostate cancers.

AB - The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. We aimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (~160 nm) and polydispersity index (~0.20). Importantly, controlled and pH-dependent drug release profiles were observed. ZNP/VB exhibited high uptake in different prostate cancer cells and, thereby, exhibited higher cytotoxicity and apoptosis. Additionally, the enhanced anti-migration effect of and induction of pro-apoptotic proteins by ZNP/VB suggest its potential effectiveness in cancer treatment. ZNP/VB showed enhanced in vivo antitumor effects compared to that observed for each free drug and their combination, with minimal toxicity. Taken together, ZNP/VB could be a potential formulation for the effective treatment of metastatic prostate cancers.

KW - Bortezomib

KW - Prostate cancer

KW - Vorinostat

KW - Zein nanoparticles

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Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers

Abstract

Keywords

UN SDGs

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