Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

Mi Hyun Hwang; Jong Hwan Lim; Hyo In Yun; Man Hee Rhee; Jae Youl Cho; Walter H. Hsu; Seung Chun Park

doi:10.1007/s10529-005-2515-1

Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

Mi Hyun Hwang
, Jong Hwan Lim
, Hyo In Yun
, Man Hee Rhee
, Jae Youl Cho
, Walter H. Hsu
, Seung Chun Park

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml ^-1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml^-1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.

Original language	English
Pages (from-to)	1605-1608
Number of pages	4
Journal	Biotechnology Letters
Volume	27
Issue number	20
DOIs	https://doi.org/10.1007/s10529-005-2515-1
State	Published - Oct 2005
Externally published	Yes

Keywords

Cyclooxygenase
Cytokine
Interleukin-1β
Nitric oxide
Surfactin

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10.1007/s10529-005-2515-1

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title = "Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells",

abstract = "The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml -1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml-1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.",

keywords = "Cyclooxygenase, Cytokine, Interleukin-1β, Nitric oxide, Surfactin",

author = "Hwang, \{Mi Hyun\} and Lim, \{Jong Hwan\} and Yun, \{Hyo In\} and Rhee, \{Man Hee\} and Cho, \{Jae Youl\} and Hsu, \{Walter H.\} and Park, \{Seung Chun\}",

year = "2005",

month = oct,

doi = "10.1007/s10529-005-2515-1",

language = "English",

volume = "27",

pages = "1605--1608",

journal = "Biotechnology Letters",

issn = "0141-5492",

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TY - JOUR

T1 - Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

AU - Hwang, Mi Hyun

AU - Lim, Jong Hwan

AU - Yun, Hyo In

AU - Rhee, Man Hee

AU - Cho, Jae Youl

AU - Hsu, Walter H.

AU - Park, Seung Chun

PY - 2005/10

Y1 - 2005/10

N2 - The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml -1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml-1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.

AB - The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml -1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml-1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.

KW - Cyclooxygenase

KW - Cytokine

KW - Interleukin-1β

KW - Nitric oxide

KW - Surfactin

UR - https://www.scopus.com/pages/publications/27144524870

U2 - 10.1007/s10529-005-2515-1

DO - 10.1007/s10529-005-2515-1

M3 - Article

C2 - 16245181

AN - SCOPUS:27144524870

SN - 0141-5492

VL - 27

SP - 1605

EP - 1608

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 20

ER -

Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

Abstract

Keywords

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