TY - GEN
T1 - Surface modification of pcl scaffold using collagen fibrillation for muscle tissue regeneration
AU - Chae, Soo Jung
AU - Lee, Jiun
AU - Lee, Jaeyoon
AU - Yeo, Miji
AU - Kim, Wonjin
AU - Kim, Geunhyung
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: In tissue engineering, development of biological substitutes or scaffolds has been studied to promote various cellular activities for repairing damaged tissues and organs [1]. Poly(ε-caprolactone) (PCL), one of the biocompatible synthetic polymers, has been widely used to fabricate 3D scaffolds. However, due to its low bioactivity it leads to low cell attachment and proliferation [2]. To overcome these limitations, collagen coating method has been used due to its simplicity [3]. However, conventional collagen coating method provided smooth surface without any topological cues. In this study, we developed a fibrillated collagen coating process to fabricate fibrillated collagen coated PCL scaffolds (FC-PCL). FC-PCL showed roughened surface topology compared with the conventionally coated scaffolds (C-PCL). Moreover, myoblast cells (C2C12) seeded onto the FC-PCL scaffolds showed greater cell alignment.
AB - Statement of Purpose: In tissue engineering, development of biological substitutes or scaffolds has been studied to promote various cellular activities for repairing damaged tissues and organs [1]. Poly(ε-caprolactone) (PCL), one of the biocompatible synthetic polymers, has been widely used to fabricate 3D scaffolds. However, due to its low bioactivity it leads to low cell attachment and proliferation [2]. To overcome these limitations, collagen coating method has been used due to its simplicity [3]. However, conventional collagen coating method provided smooth surface without any topological cues. In this study, we developed a fibrillated collagen coating process to fabricate fibrillated collagen coated PCL scaffolds (FC-PCL). FC-PCL showed roughened surface topology compared with the conventionally coated scaffolds (C-PCL). Moreover, myoblast cells (C2C12) seeded onto the FC-PCL scaffolds showed greater cell alignment.
UR - https://www.scopus.com/pages/publications/85065436891
M3 - Conference contribution
AN - SCOPUS:85065436891
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 658
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -