Supramolecular nanoencapsulation as a tool: Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with β-cyclodextrin

Gabriela Horvath; Thathan Premkumar; Ali Boztas; Eunhye Lee; Sangyong Jon; Kurt E. Geckeler

doi:10.1021/mp700144t

Supramolecular nanoencapsulation as a tool: Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with β-cyclodextrin

Gabriela Horvath
, Thathan Premkumar
, Ali Boztas
, Eunhye Lee
, Sangyong Jon
, Kurt E. Geckeler

Gwangju Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with β-cyclodextrin. The complexation was confirmed by ¹H NMR, FTIR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biological applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.

Original language	English
Pages (from-to)	358-363
Number of pages	6
Journal	Molecular Pharmaceutics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/mp700144t
State	Published - Mar 2008
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer drug
Cisplatin
Cyclodextrin
Nanoencapsulation
Platinum(II)

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10.1021/mp700144t

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title = "Supramolecular nanoencapsulation as a tool: Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with β-cyclodextrin",

abstract = "A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with β-cyclodextrin. The complexation was confirmed by 1H NMR, FTIR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biological applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.",

keywords = "Anticancer drug, Cisplatin, Cyclodextrin, Nanoencapsulation, Platinum(II)",

author = "Gabriela Horvath and Thathan Premkumar and Ali Boztas and Eunhye Lee and Sangyong Jon and Geckeler, \{Kurt E.\}",

year = "2008",

month = mar,

doi = "10.1021/mp700144t",

language = "English",

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T2 - Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with β-cyclodextrin

AU - Horvath, Gabriela

AU - Premkumar, Thathan

AU - Boztas, Ali

AU - Lee, Eunhye

AU - Jon, Sangyong

AU - Geckeler, Kurt E.

PY - 2008/3

Y1 - 2008/3

N2 - A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with β-cyclodextrin. The complexation was confirmed by 1H NMR, FTIR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biological applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.

AB - A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with β-cyclodextrin. The complexation was confirmed by 1H NMR, FTIR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biological applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.

KW - Anticancer drug

KW - Cisplatin

KW - Cyclodextrin

KW - Nanoencapsulation

KW - Platinum(II)

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DO - 10.1021/mp700144t

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AN - SCOPUS:42549121294

SN - 1543-8384

VL - 5

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EP - 363

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

IS - 2

ER -

Supramolecular nanoencapsulation as a tool: Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with β-cyclodextrin

Abstract

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Keywords

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