Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Gang Liu; Ki Young Choi; Ashwinkumar Bhirde; Magdalena Swierczewska; Juan Yin; Sang Wook Lee; Jae Hyung Park; Jong In Hong; Jin Xie; Gang Niu; Dale O. Kiesewetter; Seulki Lee; Xiaoyuan Chen

doi:10.1002/anie.201105565

Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Gang Liu
, Ki Young Choi
, Ashwinkumar Bhirde
, Magdalena Swierczewska
, Juan Yin
, Sang Wook Lee
, Jae Hyung Park
, Jong In Hong
, Jin Xie
, Gang Niu
, Dale O. Kiesewetter
, Seulki Lee
, Xiaoyuan Chen

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn ^II-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

Original language	English
Pages (from-to)	445-449
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	2
DOIs	https://doi.org/10.1002/anie.201105565
State	Published - 9 Jan 2012

Keywords

dipicolylamines
drug delivery
hyaluronic acid
nanoparticles
siRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201105565

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Liu, G., Choi, K. Y., Bhirde, A., Swierczewska, M., Yin, J., Lee, S. W., Park, J. H., Hong, J. I., Xie, J., Niu, G., Kiesewetter, D. O., Lee, S., & Chen, X. (2012). Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate. Angewandte Chemie - International Edition, 51(2), 445-449. https://doi.org/10.1002/anie.201105565

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abstract = "Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn II-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).",

keywords = "dipicolylamines, drug delivery, hyaluronic acid, nanoparticles, siRNA",

author = "Gang Liu and Choi, \{Ki Young\} and Ashwinkumar Bhirde and Magdalena Swierczewska and Juan Yin and Lee, \{Sang Wook\} and Park, \{Jae Hyung\} and Hong, \{Jong In\} and Jin Xie and Gang Niu and Kiesewetter, \{Dale O.\} and Seulki Lee and Xiaoyuan Chen",

year = "2012",

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doi = "10.1002/anie.201105565",

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Liu, G, Choi, KY, Bhirde, A, Swierczewska, M, Yin, J, Lee, SW, Park, JH, Hong, JI, Xie, J, Niu, G, Kiesewetter, DO, Lee, S & Chen, X 2012, 'Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate', Angewandte Chemie - International Edition, vol. 51, no. 2, pp. 445-449. https://doi.org/10.1002/anie.201105565

TY - JOUR

T1 - Sticky nanoparticles

T2 - A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

AU - Liu, Gang

AU - Choi, Ki Young

AU - Bhirde, Ashwinkumar

AU - Swierczewska, Magdalena

AU - Yin, Juan

AU - Lee, Sang Wook

AU - Park, Jae Hyung

AU - Hong, Jong In

AU - Xie, Jin

AU - Niu, Gang

AU - Kiesewetter, Dale O.

AU - Lee, Seulki

AU - Chen, Xiaoyuan

PY - 2012/1/9

Y1 - 2012/1/9

N2 - Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn II-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

AB - Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn II-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

KW - dipicolylamines

KW - drug delivery

KW - hyaluronic acid

KW - nanoparticles

KW - siRNA

UR - https://www.scopus.com/pages/publications/84855455777

U2 - 10.1002/anie.201105565

DO - 10.1002/anie.201105565

M3 - Article

C2 - 22110006

AN - SCOPUS:84855455777

SN - 1433-7851

VL - 51

SP - 445

EP - 449

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 2

ER -

Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Abstract

Keywords

UN SDGs

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