Stereoselective synthesis of (+)-spectaline

Yiu Suk Lee; Yong Ho Shin; Yong Hyun Kim; Kee Young Lee; Chang Young Oh; Sung Jae Pyun; Hyun Ju Park; Jin Hyun Jeong; Won Hun Ham

doi:10.1016/S0957-4166(02)00794-2

Stereoselective synthesis of (+)-spectaline

Yiu Suk Lee
, Yong Ho Shin
, Yong Hyun Kim
, Kee Young Lee
, Chang Young Oh
, Sung Jae Pyun
, Hyun Ju Park
, Jin Hyun Jeong
, Won Hun Ham

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

Original language	English
Pages (from-to)	87-93
Number of pages	7
Journal	Tetrahedron Asymmetry
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0957-4166(02)00794-2
State	Published - 6 Jan 2003

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title = "Stereoselective synthesis of (+)-spectaline",

abstract = "Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.",

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T1 - Stereoselective synthesis of (+)-spectaline

AU - Lee, Yiu Suk

AU - Shin, Yong Ho

AU - Kim, Yong Hyun

AU - Lee, Kee Young

AU - Oh, Chang Young

AU - Pyun, Sung Jae

AU - Park, Hyun Ju

AU - Jeong, Jin Hyun

AU - Ham, Won Hun

PY - 2003/1/6

Y1 - 2003/1/6

N2 - Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

AB - Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

UR - https://www.scopus.com/pages/publications/0037421233

U2 - 10.1016/S0957-4166(02)00794-2

DO - 10.1016/S0957-4166(02)00794-2

M3 - Article

AN - SCOPUS:0037421233

SN - 0957-4166

VL - 14

SP - 87

EP - 93

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 1

ER -

Stereoselective synthesis of (+)-spectaline

Abstract

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