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Statistical Methods for Conditional Survival Analysis

  • Duke University

Research output: Contribution to journalReview articlepeer-review

Abstract

We investigate the survival distribution of the patients who have survived over a certain time period. This is called a conditional survival distribution. In this paper, we show that one-sample estimation, two-sample comparison and regression analysis of conditional survival distributions can be conducted using the regular methods for unconditional survival distributions that are provided by the standard statistical software, such as SAS and SPSS. We conduct extensive simulations to evaluate the finite sample property of these conditional survival analysis methods. We illustrate these methods with real clinical data.

Original languageEnglish
Pages (from-to)927-938
Number of pages12
JournalJournal of Biopharmaceutical Statistics
Volume28
Issue number5
DOIs
StatePublished - 3 Sep 2018

Keywords

  • Delta method
  • Fieller method
  • Kaplan-Meier estimator
  • Log-rank test
  • Martingale central limit theorem
  • Proportional hazards model

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