Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure

Jung Min Ha; Won Sohn; Ju Yeon Cho; Jeung Hui Pyo; Kyu Choi; Dong Hyun Sinn; Geum Youn Gwak; Moon Seok Choi; Joon Hyeok Lee; Kwang Chul Koh; Seung Woon Paik; Byung Chul Yoo; Yong Han Paik

doi:10.3350/cmh.2015.21.3.232

Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure

Jung Min Ha, Won Sohn, Ju Yeon Cho, Jeung Hui Pyo, Kyu Choi, Dong Hyun Sinn, Geum Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Chul Koh, Seung Woon Paik, Byung Chul Yoo, Yong Han Paik

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

RESULTS: A multivariable analysis showed that the unfavorable prognostic factors were a high initial MELD score (≥28) (odds ratio [OR] =6.64, p=0.015), moderate-to-severe ascites at admission (OR=6.71, P=0.012), and the aggravation of hepatic encephalopathy during hospitalization (≥grade III) (OR=15.41, P=0.013). Compared with the baseline level, significant reductions in the MELD scores were observed on the 7th day after admission in the Recovery group (P=0.016).

CONCLUSIONS: Dynamic changes in clinical parameters during admission are useful prognostic factors for hepatitis-B-related acute-on-chronic liver failure.

BACKGROUND/AIMS: Hepatitis-B-related acute-on-chronic liver failure has a poor prognosis. However, the advent of potent oral antiviral agents means that some patients can now recover with medical treatment. We aimed to identify the prognostic factors for hepatitis-B-related acute-on-chronic liver failure including the initial as well as the dynamically changing clinical parameters during admission.

METHODS: Sixty-seven patients were retrospectively enrolled from 2003 to 2012 at Samsung Medical Center. The patients were classified into three categories: Recovery group (n=23), Liver transplantation group (n=28), and Death group (n=16). The Liver transplantation and Death groups were combined into an Unfavorable prognosis group. We analyzed the prognostic factors including the Model for End-Stage Liver Disease (MELD) scores determined at 3-day intervals.

Original language	English
Pages (from-to)	232-241
Number of pages	10
Journal	Clinical and molecular hepatology
Volume	21
Issue number	3
DOIs	https://doi.org/10.3350/cmh.2015.21.3.232
State	Published - 1 Sep 2015
Externally published	Yes

Keywords

Acute-on-chronic liver failure
Chronic hepatitis B
Liver transplantation
Model for End-Stage Liver Disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3350/cmh.2015.21.3.232

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@article{6fd74f60e24d4b8dae94e3cc7c3e026f,

title = "Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure",

abstract = "RESULTS: A multivariable analysis showed that the unfavorable prognostic factors were a high initial MELD score (≥28) (odds ratio [OR] =6.64, p=0.015), moderate-to-severe ascites at admission (OR=6.71, P=0.012), and the aggravation of hepatic encephalopathy during hospitalization (≥grade III) (OR=15.41, P=0.013). Compared with the baseline level, significant reductions in the MELD scores were observed on the 7th day after admission in the Recovery group (P=0.016).CONCLUSIONS: Dynamic changes in clinical parameters during admission are useful prognostic factors for hepatitis-B-related acute-on-chronic liver failure.BACKGROUND/AIMS: Hepatitis-B-related acute-on-chronic liver failure has a poor prognosis. However, the advent of potent oral antiviral agents means that some patients can now recover with medical treatment. We aimed to identify the prognostic factors for hepatitis-B-related acute-on-chronic liver failure including the initial as well as the dynamically changing clinical parameters during admission.METHODS: Sixty-seven patients were retrospectively enrolled from 2003 to 2012 at Samsung Medical Center. The patients were classified into three categories: Recovery group (n=23), Liver transplantation group (n=28), and Death group (n=16). The Liver transplantation and Death groups were combined into an Unfavorable prognosis group. We analyzed the prognostic factors including the Model for End-Stage Liver Disease (MELD) scores determined at 3-day intervals.",

keywords = "Acute-on-chronic liver failure, Chronic hepatitis B, Liver transplantation, Model for End-Stage Liver Disease",

author = "Ha, \{Jung Min\} and Won Sohn and Cho, \{Ju Yeon\} and Pyo, \{Jeung Hui\} and Kyu Choi and Sinn, \{Dong Hyun\} and Gwak, \{Geum Youn\} and Choi, \{Moon Seok\} and Lee, \{Joon Hyeok\} and Koh, \{Kwang Chul\} and Paik, \{Seung Woon\} and Yoo, \{Byung Chul\} and Paik, \{Yong Han\}",

year = "2015",

month = sep,

day = "1",

doi = "10.3350/cmh.2015.21.3.232",

language = "English",

volume = "21",

pages = "232--241",

journal = "Clinical and molecular hepatology",

issn = "2287-285X",

number = "3",

}

TY - JOUR

T1 - Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure

AU - Ha, Jung Min

AU - Sohn, Won

AU - Cho, Ju Yeon

AU - Pyo, Jeung Hui

AU - Choi, Kyu

AU - Sinn, Dong Hyun

AU - Gwak, Geum Youn

AU - Choi, Moon Seok

AU - Lee, Joon Hyeok

AU - Koh, Kwang Chul

AU - Paik, Seung Woon

AU - Yoo, Byung Chul

AU - Paik, Yong Han

PY - 2015/9/1

Y1 - 2015/9/1

N2 - RESULTS: A multivariable analysis showed that the unfavorable prognostic factors were a high initial MELD score (≥28) (odds ratio [OR] =6.64, p=0.015), moderate-to-severe ascites at admission (OR=6.71, P=0.012), and the aggravation of hepatic encephalopathy during hospitalization (≥grade III) (OR=15.41, P=0.013). Compared with the baseline level, significant reductions in the MELD scores were observed on the 7th day after admission in the Recovery group (P=0.016).CONCLUSIONS: Dynamic changes in clinical parameters during admission are useful prognostic factors for hepatitis-B-related acute-on-chronic liver failure.BACKGROUND/AIMS: Hepatitis-B-related acute-on-chronic liver failure has a poor prognosis. However, the advent of potent oral antiviral agents means that some patients can now recover with medical treatment. We aimed to identify the prognostic factors for hepatitis-B-related acute-on-chronic liver failure including the initial as well as the dynamically changing clinical parameters during admission.METHODS: Sixty-seven patients were retrospectively enrolled from 2003 to 2012 at Samsung Medical Center. The patients were classified into three categories: Recovery group (n=23), Liver transplantation group (n=28), and Death group (n=16). The Liver transplantation and Death groups were combined into an Unfavorable prognosis group. We analyzed the prognostic factors including the Model for End-Stage Liver Disease (MELD) scores determined at 3-day intervals.

AB - RESULTS: A multivariable analysis showed that the unfavorable prognostic factors were a high initial MELD score (≥28) (odds ratio [OR] =6.64, p=0.015), moderate-to-severe ascites at admission (OR=6.71, P=0.012), and the aggravation of hepatic encephalopathy during hospitalization (≥grade III) (OR=15.41, P=0.013). Compared with the baseline level, significant reductions in the MELD scores were observed on the 7th day after admission in the Recovery group (P=0.016).CONCLUSIONS: Dynamic changes in clinical parameters during admission are useful prognostic factors for hepatitis-B-related acute-on-chronic liver failure.BACKGROUND/AIMS: Hepatitis-B-related acute-on-chronic liver failure has a poor prognosis. However, the advent of potent oral antiviral agents means that some patients can now recover with medical treatment. We aimed to identify the prognostic factors for hepatitis-B-related acute-on-chronic liver failure including the initial as well as the dynamically changing clinical parameters during admission.METHODS: Sixty-seven patients were retrospectively enrolled from 2003 to 2012 at Samsung Medical Center. The patients were classified into three categories: Recovery group (n=23), Liver transplantation group (n=28), and Death group (n=16). The Liver transplantation and Death groups were combined into an Unfavorable prognosis group. We analyzed the prognostic factors including the Model for End-Stage Liver Disease (MELD) scores determined at 3-day intervals.

KW - Acute-on-chronic liver failure

KW - Chronic hepatitis B

KW - Liver transplantation

KW - Model for End-Stage Liver Disease

UR - https://www.scopus.com/pages/publications/85050580239

U2 - 10.3350/cmh.2015.21.3.232

DO - 10.3350/cmh.2015.21.3.232

M3 - Article

C2 - 26523268

AN - SCOPUS:85050580239

SN - 2287-285X

VL - 21

SP - 232

EP - 241

JO - Clinical and molecular hepatology

JF - Clinical and molecular hepatology

IS - 3

ER -

Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure

Abstract

Keywords

UN SDGs

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