STAPLE: Stable Alginate Gel Prepared by Linkage Exchange from Ionic to Covalent Bonds

Sang Hyeon Hong; Mikyung Shin; Junhee Lee; Ji Hyun Ryu; Suhee Lee; Jae Wook Yang; Wan Doo Kim; Haeshin Lee

doi:10.1002/adhm.201400833

STAPLE: Stable Alginate Gel Prepared by Linkage Exchange from Ionic to Covalent Bonds

Sang Hyeon Hong
, Mikyung Shin
, Junhee Lee
, Ji Hyun Ryu
, Suhee Lee
, Jae Wook Yang
, Wan Doo Kim
, Haeshin Lee

Korea Advanced Institute of Science and Technology
Korea Institute of Machinery and Materials
Inje University

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

A new Ca²⁺-alginate hydrogel with improved physical stability is prepared by covalent tethering of catechols. Ionic to covalent bond transition spontaneously occurs in physiological conditions. It is found that the kinetics of leaching out of Ca²⁺ ions from the chelated carboxylates and oxidative intercatechol cross-linking is similar, successfully maintaining the original physical shapes without conventionally performed treatment of cationic polymers on the surface Ca²⁺-alginate hydrogels.

Original language	English
Pages (from-to)	75-79
Number of pages	5
Journal	Advanced Healthcare Materials
Volume	5
Issue number	1
DOIs	https://doi.org/10.1002/adhm.201400833
State	Published - 1 Jan 2016
Externally published	Yes

Keywords

Alginate
Catechol
Hydrogel
Scaffold

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10.1002/adhm.201400833

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title = "STAPLE: Stable Alginate Gel Prepared by Linkage Exchange from Ionic to Covalent Bonds",

abstract = "A new Ca2+-alginate hydrogel with improved physical stability is prepared by covalent tethering of catechols. Ionic to covalent bond transition spontaneously occurs in physiological conditions. It is found that the kinetics of leaching out of Ca2+ ions from the chelated carboxylates and oxidative intercatechol cross-linking is similar, successfully maintaining the original physical shapes without conventionally performed treatment of cationic polymers on the surface Ca2+-alginate hydrogels.",

keywords = "Alginate, Catechol, Hydrogel, Scaffold",

author = "Hong, \{Sang Hyeon\} and Mikyung Shin and Junhee Lee and Ryu, \{Ji Hyun\} and Suhee Lee and Yang, \{Jae Wook\} and Kim, \{Wan Doo\} and Haeshin Lee",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

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doi = "10.1002/adhm.201400833",

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T2 - Stable Alginate Gel Prepared by Linkage Exchange from Ionic to Covalent Bonds

AU - Hong, Sang Hyeon

AU - Shin, Mikyung

AU - Lee, Junhee

AU - Ryu, Ji Hyun

AU - Lee, Suhee

AU - Yang, Jae Wook

AU - Kim, Wan Doo

AU - Lee, Haeshin

PY - 2016/1/1

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N2 - A new Ca2+-alginate hydrogel with improved physical stability is prepared by covalent tethering of catechols. Ionic to covalent bond transition spontaneously occurs in physiological conditions. It is found that the kinetics of leaching out of Ca2+ ions from the chelated carboxylates and oxidative intercatechol cross-linking is similar, successfully maintaining the original physical shapes without conventionally performed treatment of cationic polymers on the surface Ca2+-alginate hydrogels.

AB - A new Ca2+-alginate hydrogel with improved physical stability is prepared by covalent tethering of catechols. Ionic to covalent bond transition spontaneously occurs in physiological conditions. It is found that the kinetics of leaching out of Ca2+ ions from the chelated carboxylates and oxidative intercatechol cross-linking is similar, successfully maintaining the original physical shapes without conventionally performed treatment of cationic polymers on the surface Ca2+-alginate hydrogels.

KW - Alginate

KW - Catechol

KW - Hydrogel

KW - Scaffold

UR - https://www.scopus.com/pages/publications/84953836517

U2 - 10.1002/adhm.201400833

DO - 10.1002/adhm.201400833

M3 - Article

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EP - 79

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 1

ER -

STAPLE: Stable Alginate Gel Prepared by Linkage Exchange from Ionic to Covalent Bonds

Abstract

Keywords

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