TY - JOUR
T1 - SPIO-enhanced mri findings of well-differentiated hepatocellular carcinomas
T2 - correlation with MDCT findings
AU - Kim, Seong Hyun
AU - Lee, Won Jae
AU - Lim, Hyo K.
AU - Park, Cheol Keun
PY - 2009/4
Y1 - 2009/4
N2 - Objective: This study was designed to assess superparamagnetic iron oxide (SPIO)-enhanced MRI findings of well-differentiated hepatocellular carcinomas (HCCs) correlated with their multidetector-row CT (MDCT) findings. Materials and Methods: Seventy-two patients with 84 pathologically proven well-differentiated HCCs underwent triple-phase MDCT and SPIO-enhanced MRI at a magnetic field strength of 1.5 Tesla (n = 49) and 3.0 Tesla (n = 23). Two radiologists in consensus retrospectively reviewed the CT and MR images for attenuation value and the signal intensity of each tumor. The proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2*-weighted images were compared in terms of tumor size (< 1 cm and > 1 cm), five CT attenuation patterns based on arterial and equilibrium phases and magnetic field strength, by the use of univariate and multivariate analyses. Results: Seventy-eight (93%) and 71 (85%) HCCs were identified by CT and on SPIO-enhanced T2- and T2*-weighted images, respectively. For the CT attenuation pattern, one (14%) of seven isodense-isodense, four (67%) of six hypo- dense-hypodense, four (80%) of five isodense-hypodense, 14 (88%) of 16 hyper- dense-isodense and 48 (96%) of 50 hyperdense-hypodense HCCs were hyperintense (Cochran-Armitage test for trend, p < 0.001). Based on the use of multivariate analysis, the CT attenuation pattern was the only factor that affected the proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2*-weight- ed images (p < 0.001). Tumor size or magnetic field strength was not a factor that affected the proportion of hyperintense HCCs based on the use of univariate and multivariate analysis (p > 0.05). Conclusion: Most well differentiated HCCs showed hyperintensity on SPIO- enhanced MRI, although the lesions showed various CT attenuation patterns. The CT attenuation pattern was the main factor that affected the proportion of hyperintense well-differentiated HCCs as depicted on SPIO-enhanced MRI.
AB - Objective: This study was designed to assess superparamagnetic iron oxide (SPIO)-enhanced MRI findings of well-differentiated hepatocellular carcinomas (HCCs) correlated with their multidetector-row CT (MDCT) findings. Materials and Methods: Seventy-two patients with 84 pathologically proven well-differentiated HCCs underwent triple-phase MDCT and SPIO-enhanced MRI at a magnetic field strength of 1.5 Tesla (n = 49) and 3.0 Tesla (n = 23). Two radiologists in consensus retrospectively reviewed the CT and MR images for attenuation value and the signal intensity of each tumor. The proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2*-weighted images were compared in terms of tumor size (< 1 cm and > 1 cm), five CT attenuation patterns based on arterial and equilibrium phases and magnetic field strength, by the use of univariate and multivariate analyses. Results: Seventy-eight (93%) and 71 (85%) HCCs were identified by CT and on SPIO-enhanced T2- and T2*-weighted images, respectively. For the CT attenuation pattern, one (14%) of seven isodense-isodense, four (67%) of six hypo- dense-hypodense, four (80%) of five isodense-hypodense, 14 (88%) of 16 hyper- dense-isodense and 48 (96%) of 50 hyperdense-hypodense HCCs were hyperintense (Cochran-Armitage test for trend, p < 0.001). Based on the use of multivariate analysis, the CT attenuation pattern was the only factor that affected the proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2*-weight- ed images (p < 0.001). Tumor size or magnetic field strength was not a factor that affected the proportion of hyperintense HCCs based on the use of univariate and multivariate analysis (p > 0.05). Conclusion: Most well differentiated HCCs showed hyperintensity on SPIO- enhanced MRI, although the lesions showed various CT attenuation patterns. The CT attenuation pattern was the main factor that affected the proportion of hyperintense well-differentiated HCCs as depicted on SPIO-enhanced MRI.
UR - https://www.scopus.com/pages/publications/66749105346
U2 - 10.3348/kjr.2009.10.2.112
DO - 10.3348/kjr.2009.10.2.112
M3 - Article
C2 - 19270856
AN - SCOPUS:66749105346
SN - 1229-6929
VL - 10
SP - 112
EP - 120
JO - Korean Journal of Radiology
JF - Korean Journal of Radiology
IS - 2
ER -
