Spatial dependence of CBV-fMRI: A comparison between VASO and contrast agent based methods

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Abstract

In functional magnetic resonance imaging (fMRI), the cerebral blood volume (CSV) based approach with exogenous contrast agent has been found to have better spatial specificity than the widely applied blood oxygenation level-dependent (BOLD) method. Recently, an endogenous CSV-based contrast, vascular space occupancy-dependent (VASO) technique, was developed for human research. However, the spatial specificity of VASO functional maps is still unclear. In this report, VASO-weighted high-resolution functional map was obtained at 9.4 T. Its spatial dependence across cortical layers was compared to the traditional CSV-weighted fMRI map obtained using contrast agent injection. Both functional maps show good localization at the middle cortical layer.

Original languageEnglish
Title of host publication28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages25-28
Number of pages4
DOIs
StatePublished - 2006
Externally publishedYes
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: 30 Aug 20063 Sep 2006

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Conference

Conference28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Country/TerritoryUnited States
CityNew York, NY
Period30/08/063/09/06

Keywords

  • Cortical-layer-dependence
  • CSV-weighted
  • fMRI
  • MION
  • VASO

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