Single Cell Genomics for Tumor Heterogeneity

Hae Ock Lee; Woong Yang Park

doi:10.1007/978-981-32-9620-6_10

Single Cell Genomics for Tumor Heterogeneity

Hae Ock Lee
, Woong Yang Park

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Single cell genomics became a universal and powerful tool to study cellular diversity at genomic levels in normal and disease conditions. Cancer is a disease of genomic instability which instigates clonal evolution and intra-tumoral heterogeneity. Cancer progression also accompanies gross alterations in the microenvironment, and the stromal or immune cell types comprising the tumor microenvironment can be explored by single cell genomics. So far, breast cancer has been analyzed by single cell genomic tools for the clonal evolution, inter- and intra-tumoral heterogeneity in molecular signatures, and tumor microenvironment. We will briefly go over those studies and discuss the potential application of single cell genomics for the diagnostics and management of cancer.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	205-214
Number of pages	10
DOIs	https://doi.org/10.1007/978-981-32-9620-6_10
State	Published - 2021
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1187
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Single cell genomics
Treatment resistance
Tumor evolution
Tumor heterogeneity

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10.1007/978-981-32-9620-6_10

Cite this

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title = "Single Cell Genomics for Tumor Heterogeneity",

abstract = "Single cell genomics became a universal and powerful tool to study cellular diversity at genomic levels in normal and disease conditions. Cancer is a disease of genomic instability which instigates clonal evolution and intra-tumoral heterogeneity. Cancer progression also accompanies gross alterations in the microenvironment, and the stromal or immune cell types comprising the tumor microenvironment can be explored by single cell genomics. So far, breast cancer has been analyzed by single cell genomic tools for the clonal evolution, inter- and intra-tumoral heterogeneity in molecular signatures, and tumor microenvironment. We will briefly go over those studies and discuss the potential application of single cell genomics for the diagnostics and management of cancer.",

keywords = "Breast cancer, Single cell genomics, Treatment resistance, Tumor evolution, Tumor heterogeneity",

author = "Lee, \{Hae Ock\} and Park, \{Woong Yang\}",

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year = "2021",

doi = "10.1007/978-981-32-9620-6\_10",

language = "English",

series = "Advances in Experimental Medicine and Biology",

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AU - Lee, Hae Ock

AU - Park, Woong Yang

N1 - Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2021.

PY - 2021

Y1 - 2021

N2 - Single cell genomics became a universal and powerful tool to study cellular diversity at genomic levels in normal and disease conditions. Cancer is a disease of genomic instability which instigates clonal evolution and intra-tumoral heterogeneity. Cancer progression also accompanies gross alterations in the microenvironment, and the stromal or immune cell types comprising the tumor microenvironment can be explored by single cell genomics. So far, breast cancer has been analyzed by single cell genomic tools for the clonal evolution, inter- and intra-tumoral heterogeneity in molecular signatures, and tumor microenvironment. We will briefly go over those studies and discuss the potential application of single cell genomics for the diagnostics and management of cancer.

AB - Single cell genomics became a universal and powerful tool to study cellular diversity at genomic levels in normal and disease conditions. Cancer is a disease of genomic instability which instigates clonal evolution and intra-tumoral heterogeneity. Cancer progression also accompanies gross alterations in the microenvironment, and the stromal or immune cell types comprising the tumor microenvironment can be explored by single cell genomics. So far, breast cancer has been analyzed by single cell genomic tools for the clonal evolution, inter- and intra-tumoral heterogeneity in molecular signatures, and tumor microenvironment. We will briefly go over those studies and discuss the potential application of single cell genomics for the diagnostics and management of cancer.

KW - Breast cancer

KW - Single cell genomics

KW - Treatment resistance

KW - Tumor evolution

KW - Tumor heterogeneity

UR - https://www.scopus.com/pages/publications/85105839440

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DO - 10.1007/978-981-32-9620-6_10

M3 - Chapter

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AN - SCOPUS:85105839440

T3 - Advances in Experimental Medicine and Biology

SP - 205

EP - 214

BT - Advances in Experimental Medicine and Biology

PB - Springer

ER -

Single Cell Genomics for Tumor Heterogeneity

Abstract

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UN SDGs

Keywords

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