Silent mutations make some noise

Siyuan Zheng; Hoon Kim; Roel G.W. Verhaak

doi:10.1016/j.cell.2014.02.037

Silent mutations make some noise

Siyuan Zheng, Hoon Kim, Roel G.W. Verhaak

University of Texas MD Anderson Cancer Center

Research output: Contribution to journal › Short survey › peer-review

42 Scopus citations

Abstract

Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

Original language	English
Pages (from-to)	1129-1131
Number of pages	3
Journal	Cell
Volume	156
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2014.02.037
State	Published - 13 Mar 2014
Externally published	Yes

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10.1016/j.cell.2014.02.037

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title = "Silent mutations make some noise",

abstract = "Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.",

author = "Siyuan Zheng and Hoon Kim and Verhaak, \{Roel G.W.\}",

year = "2014",

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day = "13",

doi = "10.1016/j.cell.2014.02.037",

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TY - JOUR

T1 - Silent mutations make some noise

AU - Zheng, Siyuan

AU - Kim, Hoon

AU - Verhaak, Roel G.W.

PY - 2014/3/13

Y1 - 2014/3/13

N2 - Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

AB - Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

UR - https://www.scopus.com/pages/publications/84896360635

U2 - 10.1016/j.cell.2014.02.037

DO - 10.1016/j.cell.2014.02.037

M3 - Short survey

C2 - 24630716

AN - SCOPUS:84896360635

SN - 0092-8674

VL - 156

SP - 1129

EP - 1131

JO - Cell

JF - Cell

IS - 6

ER -

Silent mutations make some noise

Abstract

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