Shape deformity of the corpus striatum in obsessive-compulsive disorder

Jung Seok Choi; Sun Hyung Kim; So Young Yoo; Do Hyung Kang; Chi Won Kim; Jong Min Lee; In Young Kim; Sun I. Kim; Young Youn Kim; Jun Soo Kwon

doi:10.1016/j.pscychresns.2007.02.004

Shape deformity of the corpus striatum in obsessive-compulsive disorder

Jung Seok Choi, Sun Hyung Kim, So Young Yoo, Do Hyung Kang, Chi Won Kim, Jong Min Lee, In Young Kim, Sun I. Kim, Young Youn Kim, Jun Soo Kwon

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Volumetric changes of striatal structures based on magnetic resonance imaging (MRI) have been inconsistent in patients with obsessive-compulsive disorder (OCD) due to methodological limitations. The purpose of this study was to investigate shape deformities of the corpus striatum in patients with OCD. We performed 3-D shape deformation analysis of the caudate nucleus, the putamen, and the globus pallidus in 36 patients with OCD and 36 healthy normal subjects. Shape analysis showed deformity of the striatal structures, especially the caudate nucleus. Outward deformities in the superior, anterior portion of the bilateral caudate were observed in patients with OCD. In addition, an outward deformity in the inferior, lateral portion of the left putamen was also detected. These results suggest that patients with OCD have shape deformities of the corpus striatum, especially the caudate nucleus, compared with healthy normal subjects, and that shape analysis may provide an important complement to volumetric MRI studies in investigating the pathophysiology of OCD.

Original language	English
Pages (from-to)	257-264
Number of pages	8
Journal	Psychiatry Research - Neuroimaging
Volume	155
Issue number	3
DOIs	https://doi.org/10.1016/j.pscychresns.2007.02.004
State	Published - 15 Aug 2007
Externally published	Yes

Keywords

Corpus striatum
Obsessive-compulsive disorder
Shape analysis

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10.1016/j.pscychresns.2007.02.004

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title = "Shape deformity of the corpus striatum in obsessive-compulsive disorder",

abstract = "Volumetric changes of striatal structures based on magnetic resonance imaging (MRI) have been inconsistent in patients with obsessive-compulsive disorder (OCD) due to methodological limitations. The purpose of this study was to investigate shape deformities of the corpus striatum in patients with OCD. We performed 3-D shape deformation analysis of the caudate nucleus, the putamen, and the globus pallidus in 36 patients with OCD and 36 healthy normal subjects. Shape analysis showed deformity of the striatal structures, especially the caudate nucleus. Outward deformities in the superior, anterior portion of the bilateral caudate were observed in patients with OCD. In addition, an outward deformity in the inferior, lateral portion of the left putamen was also detected. These results suggest that patients with OCD have shape deformities of the corpus striatum, especially the caudate nucleus, compared with healthy normal subjects, and that shape analysis may provide an important complement to volumetric MRI studies in investigating the pathophysiology of OCD.",

keywords = "Corpus striatum, Obsessive-compulsive disorder, Shape analysis",

author = "Choi, \{Jung Seok\} and Kim, \{Sun Hyung\} and Yoo, \{So Young\} and Kang, \{Do Hyung\} and Kim, \{Chi Won\} and Lee, \{Jong Min\} and Kim, \{In Young\} and Kim, \{Sun I.\} and Kim, \{Young Youn\} and Kwon, \{Jun Soo\}",

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doi = "10.1016/j.pscychresns.2007.02.004",

language = "English",

volume = "155",

pages = "257--264",

journal = "Psychiatry Research - Neuroimaging",

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T1 - Shape deformity of the corpus striatum in obsessive-compulsive disorder

AU - Choi, Jung Seok

AU - Kim, Sun Hyung

AU - Yoo, So Young

AU - Kang, Do Hyung

AU - Kim, Chi Won

AU - Lee, Jong Min

AU - Kim, In Young

AU - Kim, Sun I.

AU - Kim, Young Youn

AU - Kwon, Jun Soo

PY - 2007/8/15

Y1 - 2007/8/15

N2 - Volumetric changes of striatal structures based on magnetic resonance imaging (MRI) have been inconsistent in patients with obsessive-compulsive disorder (OCD) due to methodological limitations. The purpose of this study was to investigate shape deformities of the corpus striatum in patients with OCD. We performed 3-D shape deformation analysis of the caudate nucleus, the putamen, and the globus pallidus in 36 patients with OCD and 36 healthy normal subjects. Shape analysis showed deformity of the striatal structures, especially the caudate nucleus. Outward deformities in the superior, anterior portion of the bilateral caudate were observed in patients with OCD. In addition, an outward deformity in the inferior, lateral portion of the left putamen was also detected. These results suggest that patients with OCD have shape deformities of the corpus striatum, especially the caudate nucleus, compared with healthy normal subjects, and that shape analysis may provide an important complement to volumetric MRI studies in investigating the pathophysiology of OCD.

AB - Volumetric changes of striatal structures based on magnetic resonance imaging (MRI) have been inconsistent in patients with obsessive-compulsive disorder (OCD) due to methodological limitations. The purpose of this study was to investigate shape deformities of the corpus striatum in patients with OCD. We performed 3-D shape deformation analysis of the caudate nucleus, the putamen, and the globus pallidus in 36 patients with OCD and 36 healthy normal subjects. Shape analysis showed deformity of the striatal structures, especially the caudate nucleus. Outward deformities in the superior, anterior portion of the bilateral caudate were observed in patients with OCD. In addition, an outward deformity in the inferior, lateral portion of the left putamen was also detected. These results suggest that patients with OCD have shape deformities of the corpus striatum, especially the caudate nucleus, compared with healthy normal subjects, and that shape analysis may provide an important complement to volumetric MRI studies in investigating the pathophysiology of OCD.

KW - Corpus striatum

KW - Obsessive-compulsive disorder

KW - Shape analysis

UR - https://www.scopus.com/pages/publications/34447268491

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DO - 10.1016/j.pscychresns.2007.02.004

M3 - Article

C2 - 17572074

AN - SCOPUS:34447268491

SN - 0925-4927

VL - 155

SP - 257

EP - 264

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

IS - 3

ER -

Shape deformity of the corpus striatum in obsessive-compulsive disorder

Abstract

Keywords

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