Abstract
Serum uric acid (SUA) is a potential risk factor for atherosclerosis. We assessed the relationship between SUA and subclinical atherosclerosis in Korean men (n = 3010). Multidetector computed tomography (MDCT) and ultrasonographic measurements of coronary artery calcification (CAC) and carotid intima-media thickness (cIMT), respectively, are markers of subclinical atherosclerosis. Odds ratios (ORs) of CAC score and cIMT across SUA levels were 1.101 (P =.046) and 1.266 (P =.002), respectively, after adjustment for several variables. The independent association between CAC and cIMT was observed (OR = 1.231, P <.001). Serum uric acid was independently associated with metabolic syndrome (MetS) with an OR of 1.415 (P <.001). Metabolic syndrome was only independently associated with cIMT, with an OR of 2.103 (P =.003). High-sensitivity C-reactive protein was positively correlated with SUA (r =.125, P <.001). Serum uric acid level is independently associated with CAC, cIMT, and MetS in Korean men.
| Original language | English |
|---|---|
| Pages (from-to) | 420-428 |
| Number of pages | 9 |
| Journal | Angiology |
| Volume | 63 |
| Issue number | 6 |
| DOIs | |
| State | Published - Aug 2012 |
| Externally published | Yes |
Keywords
- carotid intima-media thickness
- coronary artery calcification
- high-sensitivity C-reactive protein
- metabolic syndrome
- serum uric acid
