Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity

Sang Jip Nam; Hyunsil Ko; Kyeong Ju Moon; Hoosang Hwang; Jungwook Chin; Jungyeob Ham; Byoungchan Lee; Jaehwan Lee; Hwan Won Dong; Hyukjae Choi; Jaeyoung Ko; Kyoungjin Shin; Taekyung Oh; Seokho Kim; Jung Rae Rho; Heonjoong Kang

doi:10.1021/np070024k

Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity

Sang Jip Nam
, Hyunsil Ko
, Kyeong Ju Moon
, Hoosang Hwang
, Jungwook Chin
, Jungyeob Ham
, Byoungchan Lee
, Jaehwan Lee
, Hwan Won Dong
, Hyukjae Choi
, Jaeyoung Ko
, Kyoungjin Shin
, Taekyung Oh
, Seokho Kim
, Jung Rae Rho
, Heonjoong Kang

Seoul National University
Korea Institute of Science and Technology
Kunsan National University

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Three new scalarane-based sesterterpenes, 1-3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC ₅₀ values of 2.4 and 24 μM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy.

Original language	English
Pages (from-to)	1691-1695
Number of pages	5
Journal	Journal of Natural Products
Volume	70
Issue number	11
DOIs	https://doi.org/10.1021/np070024k
State	Published - Nov 2007
Externally published	Yes

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title = "Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity",

abstract = "Three new scalarane-based sesterterpenes, 1-3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC 50 values of 2.4 and 24 μM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy.",

author = "Nam, \{Sang Jip\} and Hyunsil Ko and Moon, \{Kyeong Ju\} and Hoosang Hwang and Jungwook Chin and Jungyeob Ham and Byoungchan Lee and Jaehwan Lee and Dong, \{Hwan Won\} and Hyukjae Choi and Jaeyoung Ko and Kyoungjin Shin and Taekyung Oh and Seokho Kim and Rho, \{Jung Rae\} and Heonjoong Kang",

year = "2007",

month = nov,

doi = "10.1021/np070024k",

language = "English",

volume = "70",

pages = "1691--1695",

journal = "Journal of Natural Products",

issn = "0163-3864",

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TY - JOUR

T1 - Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity

AU - Nam, Sang Jip

AU - Ko, Hyunsil

AU - Moon, Kyeong Ju

AU - Hwang, Hoosang

AU - Chin, Jungwook

AU - Ham, Jungyeob

AU - Lee, Byoungchan

AU - Lee, Jaehwan

AU - Dong, Hwan Won

AU - Choi, Hyukjae

AU - Ko, Jaeyoung

AU - Shin, Kyoungjin

AU - Oh, Taekyung

AU - Kim, Seokho

AU - Rho, Jung Rae

AU - Kang, Heonjoong

PY - 2007/11

Y1 - 2007/11

N2 - Three new scalarane-based sesterterpenes, 1-3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC 50 values of 2.4 and 24 μM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy.

AB - Three new scalarane-based sesterterpenes, 1-3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC 50 values of 2.4 and 24 μM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy.

UR - https://www.scopus.com/pages/publications/37249092686

U2 - 10.1021/np070024k

DO - 10.1021/np070024k

M3 - Article

C2 - 17988093

AN - SCOPUS:37249092686

SN - 0163-3864

VL - 70

SP - 1691

EP - 1695

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity

Abstract

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