Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Seung Kuk Baek; Myung Chul Lee; J. Hun Hah; Soon Hyun Ahn; Young Ik Son; Young Soo Rho; Phil Sang Chung; Yoon Se Lee; Bon Seok Koo; Kwang Yoon Jung; Byung Joo Lee

doi:10.1002/hed.24559

Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Seung Kuk Baek
, Myung Chul Lee
, J. Hun Hah
, Soon Hyun Ahn
, Young Ik Son
, Young Soo Rho
, Phil Sang Chung
, Yoon Se Lee
, Bon Seok Koo
, Kwang Yoon Jung
, Byung Joo Lee

Korea University
Korea Institute of Radiological and Medical Sciences
Seoul National University
Sungkyunkwan University
Hallym University
Dankook University
University of Ulsan
Chungnam National University
Pusan National University

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Background: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.

Original language	English
Pages (from-to)	133-139
Number of pages	7
Journal	Head and Neck
Volume	39
Issue number	1
DOIs	https://doi.org/10.1002/hed.24559
State	Published - 1 Jan 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anaplastic thyroid carcinoma
multicenter study
multimodal treatment
prognostic factor
surgery

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10.1002/hed.24559

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Baek, S. K., Lee, M. C., Hah, J. H., Ahn, S. H., Son, Y. I., Rho, Y. S., Chung, P. S., Lee, Y. S., Koo, B. S., Jung, K. Y., & Lee, B. J. (2017). Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012. Head and Neck, 39(1), 133-139. https://doi.org/10.1002/hed.24559

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title = "Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012",

abstract = "Background: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.",

keywords = "anaplastic thyroid carcinoma, multicenter study, multimodal treatment, prognostic factor, surgery",

author = "Baek, \{Seung Kuk\} and Lee, \{Myung Chul\} and Hah, \{J. Hun\} and Ahn, \{Soon Hyun\} and Son, \{Young Ik\} and Rho, \{Young Soo\} and Chung, \{Phil Sang\} and Lee, \{Yoon Se\} and Koo, \{Bon Seok\} and Jung, \{Kwang Yoon\} and Lee, \{Byung Joo\}",

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year = "2017",

month = jan,

day = "1",

doi = "10.1002/hed.24559",

language = "English",

volume = "39",

pages = "133--139",

journal = "Head and Neck",

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TY - JOUR

T1 - Role of surgery in the management of anaplastic thyroid carcinoma

T2 - Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

AU - Baek, Seung Kuk

AU - Lee, Myung Chul

AU - Hah, J. Hun

AU - Ahn, Soon Hyun

AU - Son, Young Ik

AU - Rho, Young Soo

AU - Chung, Phil Sang

AU - Lee, Yoon Se

AU - Koo, Bon Seok

AU - Jung, Kwang Yoon

AU - Lee, Byung Joo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.

AB - Background: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.

KW - anaplastic thyroid carcinoma

KW - multicenter study

KW - multimodal treatment

KW - prognostic factor

KW - surgery

UR - https://www.scopus.com/pages/publications/84994461649

U2 - 10.1002/hed.24559

DO - 10.1002/hed.24559

M3 - Article

C2 - 27534388

AN - SCOPUS:84994461649

SN - 1043-3074

VL - 39

SP - 133

EP - 139

JO - Head and Neck

JF - Head and Neck

IS - 1

ER -

Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Abstract

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Keywords

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