TY - JOUR
T1 - Risk for coronary heart disease increases risk for colorectal neoplasm
AU - Lee, Ji Young
AU - Hong, Sung Noh
AU - Kim, Jeong Hwan
AU - Choe, Won Hyeok
AU - Lee, Sun Young
AU - Sung, In Kyung
AU - Park, Hyung Seok
AU - Shim, Chan Sup
PY - 2013/6
Y1 - 2013/6
N2 - BACKGROUND and AIMS: Colorectal neoplasms and coronary artery disease have similar risk factors. Patients with established coronary artery disease have a high prevalence of colorectal neoplasms. However, little is known about the risk of colorectal neoplasms among individuals at risk for coronary artery disease. METHODS: We performed a cross-sectional study of 3144 asymptomatic, average-risk individuals without history of coronary artery disease or other vascular disorders who received a screening colonoscopy examination from January to December 2010 at Konkuk University Medical Center in Seoul, Korea. Participants were classified as having low (<10%), intermediate (10%-20%), or high (>20%) risk for developing coronary artery disease in the next 10 years, which was based on Framingham/Adult Treatment Panel III risk scores. RESULTS: The prevalence of colorectal neoplasms in subjects with low, intermediate, and high risk for coronary artery disease was 25.6% (635/2485), 46.6% (252/541), and 53.4% (63/118), respectively (P < 001); the prevalence of advanced colorectal neoplasms was 4.9% (122/2485), 9.2% (50/541), and 17.8% (21/118), respectively, for these subjects (P < 001). In multivariate analyses, the high-risk group had a significantly increased risk of advanced colorectal neoplasm (odds ratio, 3.31; 95% confidence interval [CI], 1.94-5.65), compared with the low-risk group. The numbers of colonoscopies needed to identify individuals with advanced colorectal neoplasms in intermediate-risk and high-risk groups were 10.8 (95% CI, 8.6 -14.7) and 5.6 (95% CI, 7.6 -11.9), respectively, which were significantly lower than for the low-risk group (20.4; 95% CI, 17.4 -24.6). CONCLUSIONS: The prevalence and the risk of overall and advanced colorectal neoplasms increase with risk of coronary artery disease. Individuals with a 10-year risk of coronary artery disease >10% might benefit from colonoscopy screening, but further studies are needed to confirm and generalize these results.
AB - BACKGROUND and AIMS: Colorectal neoplasms and coronary artery disease have similar risk factors. Patients with established coronary artery disease have a high prevalence of colorectal neoplasms. However, little is known about the risk of colorectal neoplasms among individuals at risk for coronary artery disease. METHODS: We performed a cross-sectional study of 3144 asymptomatic, average-risk individuals without history of coronary artery disease or other vascular disorders who received a screening colonoscopy examination from January to December 2010 at Konkuk University Medical Center in Seoul, Korea. Participants were classified as having low (<10%), intermediate (10%-20%), or high (>20%) risk for developing coronary artery disease in the next 10 years, which was based on Framingham/Adult Treatment Panel III risk scores. RESULTS: The prevalence of colorectal neoplasms in subjects with low, intermediate, and high risk for coronary artery disease was 25.6% (635/2485), 46.6% (252/541), and 53.4% (63/118), respectively (P < 001); the prevalence of advanced colorectal neoplasms was 4.9% (122/2485), 9.2% (50/541), and 17.8% (21/118), respectively, for these subjects (P < 001). In multivariate analyses, the high-risk group had a significantly increased risk of advanced colorectal neoplasm (odds ratio, 3.31; 95% confidence interval [CI], 1.94-5.65), compared with the low-risk group. The numbers of colonoscopies needed to identify individuals with advanced colorectal neoplasms in intermediate-risk and high-risk groups were 10.8 (95% CI, 8.6 -14.7) and 5.6 (95% CI, 7.6 -11.9), respectively, which were significantly lower than for the low-risk group (20.4; 95% CI, 17.4 -24.6). CONCLUSIONS: The prevalence and the risk of overall and advanced colorectal neoplasms increase with risk of coronary artery disease. Individuals with a 10-year risk of coronary artery disease >10% might benefit from colonoscopy screening, but further studies are needed to confirm and generalize these results.
UR - https://www.scopus.com/pages/publications/84878134548
U2 - 10.1016/j.cgh.2012.10.017
DO - 10.1016/j.cgh.2012.10.017
M3 - Article
C2 - 23078887
AN - SCOPUS:84878134548
SN - 1542-3565
VL - 11
SP - 695
EP - 702
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 6
ER -
