Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins: A new strategy for 2,3-dihydro-1H-indazoles

Sangil Han; Youngmi Shin; Satyasheel Sharma; Neeraj Kumar Mishra; Jihye Park; Mirim Kim; Minyoung Kim; Jinbong Jang; In Su Kim

doi:10.1021/ol500865j

Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins: A new strategy for 2,3-dihydro-1H-indazoles

Sangil Han
, Youngmi Shin
, Satyasheel Sharma
, Neeraj Kumar Mishra
, Jihye Park
, Mirim Kim
, Minyoung Kim
, Jinbong Jang
, In Su Kim

Department of Pharmacy

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp² C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of highly substituted 2,3-dihydro-1H-indazole scaffolds.

Original language	English
Pages (from-to)	2494-2497
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	9
DOIs	https://doi.org/10.1021/ol500865j
State	Published - 2 May 2014

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title = "Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins: A new strategy for 2,3-dihydro-1H-indazoles",

abstract = "A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp2 C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of highly substituted 2,3-dihydro-1H-indazole scaffolds.",

author = "Sangil Han and Youngmi Shin and Satyasheel Sharma and Mishra, \{Neeraj Kumar\} and Jihye Park and Mirim Kim and Minyoung Kim and Jinbong Jang and Kim, \{In Su\}",

year = "2014",

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doi = "10.1021/ol500865j",

language = "English",

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journal = "Organic Letters",

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T1 - Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins

T2 - A new strategy for 2,3-dihydro-1H-indazoles

AU - Han, Sangil

AU - Shin, Youngmi

AU - Sharma, Satyasheel

AU - Mishra, Neeraj Kumar

AU - Park, Jihye

AU - Kim, Mirim

AU - Kim, Minyoung

AU - Jang, Jinbong

AU - Kim, In Su

PY - 2014/5/2

Y1 - 2014/5/2

N2 - A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp2 C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of highly substituted 2,3-dihydro-1H-indazole scaffolds.

AB - A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp2 C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of highly substituted 2,3-dihydro-1H-indazole scaffolds.

UR - https://www.scopus.com/pages/publications/84899883674

U2 - 10.1021/ol500865j

DO - 10.1021/ol500865j

M3 - Article

C2 - 24754303

AN - SCOPUS:84899883674

SN - 1523-7060

VL - 16

SP - 2494

EP - 2497

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins: A new strategy for 2,3-dihydro-1H-indazoles

Abstract

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