Rh(III)-catalyzed C−H alkylation of indolines with enones through conjugate addition and protonation pathway

Hyunjung Oh; Jihye Park; Sang Hoon Han; Neeraj Kumar Mishra; Suk Hun Lee; Yongguk Oh; Mijin Jeon; Gyeong Joo Seong; Ka Young Chung; In Su Kim

doi:10.1016/j.tet.2017.06.052

Rh(III)-catalyzed C−H alkylation of indolines with enones through conjugate addition and protonation pathway

Hyunjung Oh
, Jihye Park
, Sang Hoon Han
, Neeraj Kumar Mishra
, Suk Hun Lee
, Yongguk Oh
, Mijin Jeon
, Gyeong Joo Seong
, Ka Young Chung
, In Su Kim

Department of Pharmacy

Sungkyunkwan University
Konyang University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The rhodium(III)-catalyzed C−H alkylations of indolines with enones and enals is described. This reaction can proceed through 1,4-conjugate addition and protonation process providing β-indolinic ketone compounds, which are known to be crucial scaffolds of biologically active compounds.

Original language	English
Pages (from-to)	4739-4749
Number of pages	11
Journal	Tetrahedron
Volume	73
Issue number	32
DOIs	https://doi.org/10.1016/j.tet.2017.06.052
State	Published - 2017

Keywords

Alkylation
Conjugate addition
Enones
Indolines
Rhodium

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10.1016/j.tet.2017.06.052

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title = "Rh(III)-catalyzed C−H alkylation of indolines with enones through conjugate addition and protonation pathway",

abstract = "The rhodium(III)-catalyzed C−H alkylations of indolines with enones and enals is described. This reaction can proceed through 1,4-conjugate addition and protonation process providing β-indolinic ketone compounds, which are known to be crucial scaffolds of biologically active compounds.",

keywords = "Alkylation, Conjugate addition, Enones, Indolines, Rhodium",

author = "Hyunjung Oh and Jihye Park and Han, \{Sang Hoon\} and Mishra, \{Neeraj Kumar\} and Lee, \{Suk Hun\} and Yongguk Oh and Mijin Jeon and Seong, \{Gyeong Joo\} and Chung, \{Ka Young\} and Kim, \{In Su\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.tet.2017.06.052",

language = "English",

volume = "73",

pages = "4739--4749",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "32",

}

TY - JOUR

T1 - Rh(III)-catalyzed C−H alkylation of indolines with enones through conjugate addition and protonation pathway

AU - Oh, Hyunjung

AU - Park, Jihye

AU - Han, Sang Hoon

AU - Mishra, Neeraj Kumar

AU - Lee, Suk Hun

AU - Oh, Yongguk

AU - Jeon, Mijin

AU - Seong, Gyeong Joo

AU - Chung, Ka Young

AU - Kim, In Su

PY - 2017

Y1 - 2017

N2 - The rhodium(III)-catalyzed C−H alkylations of indolines with enones and enals is described. This reaction can proceed through 1,4-conjugate addition and protonation process providing β-indolinic ketone compounds, which are known to be crucial scaffolds of biologically active compounds.

AB - The rhodium(III)-catalyzed C−H alkylations of indolines with enones and enals is described. This reaction can proceed through 1,4-conjugate addition and protonation process providing β-indolinic ketone compounds, which are known to be crucial scaffolds of biologically active compounds.

KW - Alkylation

KW - Conjugate addition

KW - Enones

KW - Indolines

KW - Rhodium

UR - https://www.scopus.com/pages/publications/85021417865

U2 - 10.1016/j.tet.2017.06.052

DO - 10.1016/j.tet.2017.06.052

M3 - Article

AN - SCOPUS:85021417865

SN - 0040-4020

VL - 73

SP - 4739

EP - 4749

JO - Tetrahedron

JF - Tetrahedron

IS - 32

ER -

Rh(III)-catalyzed C−H alkylation of indolines with enones through conjugate addition and protonation pathway

Abstract

Keywords

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