Regulation of IL-17 in atherosclerosis and related autoimmunity

Heeju Ryu; Yeonseok Chung

doi:10.1016/j.cyto.2015.03.009

Regulation of IL-17 in atherosclerosis and related autoimmunity

Heeju Ryu
, Yeonseok Chung

Seoul National University

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate autoimmune diseases in humans as well as in experimental animal. How atherosclerosis impacts autoimmunity remains poorly understood. Importantly, recent studies showed that several pro-atherogenic factors including cholesterol, oxidized low-density lipoprotein and fatty acids regulate the production of IL-17 and IL-17-promoting cytokines from innate and adaptive immune cells. Given that IL-17 is associated with a number of autoimmune diseases in humans, dissecting the mechanisms beyond the mutual regulation of pro-atherogenic factors and IL-17 might provide a novel pathophysiology between atherosclerosis and autoimmune diseases. In this review, we discuss our current understanding related to the role of pro-atherogenic factors in IL-17 production and autoimmune diseases.

Original language	English
Pages (from-to)	219-227
Number of pages	9
Journal	Cytokine
Volume	74
Issue number	2
DOIs	https://doi.org/10.1016/j.cyto.2015.03.009
State	Published - 3 Dec 2015
Externally published	Yes

Keywords

Autoimmunity
Hyperlipidemia
IL-17
Low-density lipoprotein
Th17 cell

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10.1016/j.cyto.2015.03.009

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title = "Regulation of IL-17 in atherosclerosis and related autoimmunity",

abstract = "Patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate autoimmune diseases in humans as well as in experimental animal. How atherosclerosis impacts autoimmunity remains poorly understood. Importantly, recent studies showed that several pro-atherogenic factors including cholesterol, oxidized low-density lipoprotein and fatty acids regulate the production of IL-17 and IL-17-promoting cytokines from innate and adaptive immune cells. Given that IL-17 is associated with a number of autoimmune diseases in humans, dissecting the mechanisms beyond the mutual regulation of pro-atherogenic factors and IL-17 might provide a novel pathophysiology between atherosclerosis and autoimmune diseases. In this review, we discuss our current understanding related to the role of pro-atherogenic factors in IL-17 production and autoimmune diseases.",

keywords = "Autoimmunity, Hyperlipidemia, IL-17, Low-density lipoprotein, Th17 cell",

author = "Heeju Ryu and Yeonseok Chung",

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T1 - Regulation of IL-17 in atherosclerosis and related autoimmunity

AU - Ryu, Heeju

AU - Chung, Yeonseok

PY - 2015/12/3

Y1 - 2015/12/3

N2 - Patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate autoimmune diseases in humans as well as in experimental animal. How atherosclerosis impacts autoimmunity remains poorly understood. Importantly, recent studies showed that several pro-atherogenic factors including cholesterol, oxidized low-density lipoprotein and fatty acids regulate the production of IL-17 and IL-17-promoting cytokines from innate and adaptive immune cells. Given that IL-17 is associated with a number of autoimmune diseases in humans, dissecting the mechanisms beyond the mutual regulation of pro-atherogenic factors and IL-17 might provide a novel pathophysiology between atherosclerosis and autoimmune diseases. In this review, we discuss our current understanding related to the role of pro-atherogenic factors in IL-17 production and autoimmune diseases.

AB - Patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate autoimmune diseases in humans as well as in experimental animal. How atherosclerosis impacts autoimmunity remains poorly understood. Importantly, recent studies showed that several pro-atherogenic factors including cholesterol, oxidized low-density lipoprotein and fatty acids regulate the production of IL-17 and IL-17-promoting cytokines from innate and adaptive immune cells. Given that IL-17 is associated with a number of autoimmune diseases in humans, dissecting the mechanisms beyond the mutual regulation of pro-atherogenic factors and IL-17 might provide a novel pathophysiology between atherosclerosis and autoimmune diseases. In this review, we discuss our current understanding related to the role of pro-atherogenic factors in IL-17 production and autoimmune diseases.

KW - Autoimmunity

KW - Hyperlipidemia

KW - IL-17

KW - Low-density lipoprotein

KW - Th17 cell

UR - https://www.scopus.com/pages/publications/84949724272

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DO - 10.1016/j.cyto.2015.03.009

M3 - Review article

C2 - 25890878

AN - SCOPUS:84949724272

SN - 1043-4666

VL - 74

SP - 219

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JO - Cytokine

JF - Cytokine

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ER -

Regulation of IL-17 in atherosclerosis and related autoimmunity

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Keywords

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